Pharmacology study of the neutral myocardial imaging agent technetium-99m-N(NOEt)2.
J Nucl Med Technol
; 27(1): 54-6, 1999 Mar.
Article
en En
| MEDLINE
| ID: mdl-10322579
OBJECTIVE: The biological properties of a new neutral myocardial imaging agent 99mTcN(NOEt)2 were evaluated. METHODS: Blood clearance in rabbits, biodistribution in rats, and initial myocardial imaging in dogs were performed. RESULTS: Radiochemical purity of 99mTcN(NOEt)2 was more than 90% and stable for 6 h at room temperature. Blood disappearance was analyzed with a biexponential model and T1/2(alpha) = 2.53 min, T1/2(beta) = 330 min and CI = 378 ml/h were obtained. Biodistribution studies demonstrated that 99mTcN(NOEt)2 localized selectively in the rat myocardium. Cardiac uptakes were 4.69, 4.20, 3.95 and 3.43% ID/g at 5, 30, 60 and 90 min postinjection, respectively. The mean heart-to-lung activity ratios were 1.69, 2.40 and 2.55 at 10 min, 30 min and 60 min postinjection, respectively. CONCLUSION: Technetium-99m-N(NOEt)2 exhibited favorable stability and biological properties. Further study in humans is required.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Tiocarbamatos
/
Compuestos de Organotecnecio
/
Corazón
Límite:
Animals
Idioma:
En
Revista:
J Nucl Med Technol
Año:
1999
Tipo del documento:
Article
Pais de publicación:
Estados Unidos