The mouse major histocompatibility complex: some assembly required.

Amadou, C; Kumánovics, A; Jones, E P; Lambracht-Washington, D; Yoshino, M; Lindahl, K F

Amadou, C; Kumánovics, A; Jones, E P; Lambracht-Washington, D; Yoshino, M; Lindahl, K F.

Afiliación

Amadou C; Howard Hughes Medical Institute, University of Texas Southwestern Medical Center, Dallas, USA.

Immunol Rev ; 167: 211-21, 1999 Feb.

Article en En | MEDLINE | ID: mdl-10319263

RESUMEN

We have assembled a contig of 81 yeast artificial chromosome clones that spans 8 Mb and contains the entire major histocompatibility complex (Mhc) from mouse strain C57BL/6 (H2b), and we are in the process of assembling an Mhc contig of bacterial artificial chromosome (BAC) clones from strain 129 (H2bc), which differs from C57BL/6 in the H2-Q and H2-T regions. The current BAC contig extends from Tapasin to D17Leh89 with gaps in the class II, H2-Q, and distal H2-M regions. Only four BAC clones were required to link the class I genes of the H2-Q and H2-T regions, and no new class I gene was found in the previous gap. The proximal 1 Mb of the H2-M region has been analyzed in detail and is ready for sequencing; it includes 21 class I genes or fragments, at least 14 olfactory receptor-like genes, and a number of non-class I genes that clearly establish a conserved synteny with the class I regions of the human and rat Mhc.

Asunto(s)

Antígenos H-2/genética; Complejo Mayor de Histocompatibilidad/genética; Animales; Mapeo Contig; Humanos; Ratones; Ratones Endogámicos C57BL

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Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Antígenos H-2 / Complejo Mayor de Histocompatibilidad Límite: Animals / Humans Idioma: En Revista: Immunol Rev Año: 1999 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Reino Unido

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