Chitin synthase II inhibitory activity of ursolic acid, isolated from Crataegus pinnatifida.

Jeong, T S; Hwang, E I; Lee, H B; Lee, E S; Kim, Y K; Min, B S; Bae, K H; Bok, S H; Kim, S U

Jeong, T S; Hwang, E I; Lee, H B; Lee, E S; Kim, Y K; Min, B S; Bae, K H; Bok, S H; Kim, S U.

Planta Med ; 65(3): 261-3, 1999 Apr.

Article en En | MEDLINE | ID: mdl-10232075

RESUMEN

Two triterpenoid compounds, ursolic acid and uvaol, were isolated from Crataegus pinnatifida Bunge leaves. Ursolic acid inhibits chitin synthase II from S. cerevisiae with an IC50 value of 0.84 microgram/ml and the inhibition appears to be selective for chitin synthase II, whereas uvaol has no inhibitory activity up to 280 micrograms/ml. Oleanolic acid, alpha-hederin hydrate, and betulic acid inhibited the chitin synthase II activity under the same conditions with an IC50 of 5.6, 64.3, and 98.7 micrograms/ml, respectively.

Asunto(s)

Quitina Sintasa/antagonistas & inhibidores; Inhibidores Enzimáticos/farmacología; Rosales/química; Triterpenos/farmacología; Inhibidores Enzimáticos/química; Inhibidores Enzimáticos/aislamiento & purificación; Saccharomyces cerevisiae/enzimología; Triterpenos/química; Triterpenos/aislamiento & purificación; Ácido Ursólico

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Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Triterpenos / Quitina Sintasa / Rosales / Inhibidores Enzimáticos Idioma: En Revista: Planta Med Año: 1999 Tipo del documento: Article Pais de publicación: Alemania

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