Feasibility of a preventive HIV-1 vaccine cohort among persons attending sexually transmitted disease clinics in Thailand.
J Acquir Immune Defic Syndr Hum Retrovirol
; 20(5): 488-94, 1999 Apr 15.
Article
en En
| MEDLINE
| ID: mdl-10225232
ABSTRACT
PIP: Thailand is one of the few countries in which plans for HIV-1 vaccine efficacy trials are proceeding. The determination of cohort sample size for such trials depends upon the HIV-1 incidence among those who may enroll in the trials, participant retention, trial duration, and the frequency of risk behavior during the trial. The authors conducted a prospective cohort study of sexually transmitted disease (STD) clinic attendees at 3 sites in Thailand to determine whether a cohort in the population would be suitable for future HIV-1 vaccine efficacy trials. Between September 1995 and February 1996, 371 of 1205 (31%) eligible men and 161 of 659 (24%) eligible women agreed to participate in a 1-year study of HIV-1 incidence. At enrollment, 3.8% of the men and 2.5% of the women were infected with HIV-1. Almost all women and 54% of the men were married at the time of enrollment. 78% of the 514 participants who were seronegative at baseline were still being followed at the 12-month visit. During the study period, 53% of men reported having 2 or more sex partners, 31% reported having sex with a prostitute, and 33% with a casual partner. 72% of those frequenting prostitutes reported consistent condom use. 11% of women reported 2 or more sex partners. Decreased HIV risk behaviors among men were observed during the study. 4 incident infections occurred in men and none among the women. Based upon this observed HIV-1 infection incidence, HIV vaccine efficacy trials in such populations would have to be larger than previously planned or more selective of high-risk subgroups for recruitment.
Palabras clave
Acquired Immunodeficiency Syndrome; Asia; Clients; Clinical Research; Clinical Trials; Cohort Analysis; Developing Countries; Diseases; Hiv Infections; Incidence; Infections; Measurement; Organization And Administration; Prevalence; Program Activities; Programs; Reproductive Tract Infections; Research Methodology; Research Report; Sexually Transmitted Diseases; Southeastern Asia; Thailand; Vaccines; Viral Diseases
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Infecciones por VIH
/
VIH-1
/
Vacunas contra el SIDA
Tipo de estudio:
Etiology_studies
/
Observational_studies
/
Prevalence_studies
/
Prognostic_studies
/
Risk_factors_studies
Límite:
Adult
/
Female
/
Humans
/
Male
País/Región como asunto:
Asia
Idioma:
En
Revista:
J Acquir Immune Defic Syndr Hum Retrovirol
Asunto de la revista:
SINDROME DA IMUNODEFICIENCIA ADQUIRIDA (AIDS)
/
VIROLOGIA
Año:
1999
Tipo del documento:
Article
País de afiliación:
Tailandia
Pais de publicación:
Estados Unidos