Your browser doesn't support javascript.
loading
Serum leptin concentrations in women taking oral contraceptives.
Rechberger, T; Baranowski, W; Postawski, K; Jakimiuk, A J; Tomaszewski, J; Kulik-Rechberger, B; Jakowicki, J A.
Afiliación
  • Rechberger T; Department of Gynecological Surgery, University School of Medicine, Lublin, Poland. skorup@eskulap.am.lublin.pl
Eur J Obstet Gynecol Reprod Biol ; 83(1): 105-8, 1999 Mar.
Article en En | MEDLINE | ID: mdl-10221618
OBJECTIVES: To investigate serum leptin concentrations in women taking oral contraceptives containing the same gestagen and different doses of ethinyl estradiol. STUDY DESIGN: 30 women received tablets containing 20 microg of ethinyl estradiol (EE) and 150 microg of desogestrel (DSG) (Mercilon) whereas another group of 30 women received 30 microg of EE and 150 microg of DSG (Marvelon). Serum leptin concentrations were estimated using a Leptin RIA kit (Linco Research USA) after an overnight fast on the first day of the cycle prior to the onset of therapy as well as after the 3rd and 6th treated cycles. RESULTS: In both groups a positive correlation between serum leptin and body mass index (BMI) was found (r=0.56; P<0.001 and r=0.67; P<0.001). The initial serum leptin concentration in the Mercilon group was 7.62+/-8.46 ng/ml. This value was not statistically different from values after 3 months (9.31 8.23 ng/ml) and after 6 months (10.53+/-8.03 ng/ml) of treatment. Very similar results were found in patients receiving Marvelon: 8.81+/-6.56 ng/ml initially; 11.62+/-11.16 ng/ml at 3 months, and 10.38+/-7.32 ng/ml at 6 months. The statistical analysis did not reveal any significant difference at each investigated time point in either study group. CONCLUSIONS: Modern low dose OC containing third generation gestagen and low dose of ethinyl estradiol, does not have any influence on serum leptin or BMI, and therefore does not exert a significant influence on body energy metabolism.
Asunto(s)
Buscar en Google
Añadir a Mi BVS
Imprimir
XML
PubMed Links

Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Proteínas / Tejido Adiposo / Desogestrel / Anticonceptivos Orales Combinados / Anticonceptivos Hormonales Orales / Etinilestradiol Límite: Female / Humans Idioma: En Revista: Eur J Obstet Gynecol Reprod Biol Año: 1999 Tipo del documento: Article País de afiliación: Polonia Pais de publicación: Irlanda
Buscar en Google
Añadir a Mi BVS
Imprimir
XML
PubMed Links

Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Proteínas / Tejido Adiposo / Desogestrel / Anticonceptivos Orales Combinados / Anticonceptivos Hormonales Orales / Etinilestradiol Límite: Female / Humans Idioma: En Revista: Eur J Obstet Gynecol Reprod Biol Año: 1999 Tipo del documento: Article País de afiliación: Polonia Pais de publicación: Irlanda