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Pregnane glycoside multidrug-resistance modulators from Cynanchum wilfordii.
Hwang, B Y; Kim, S E; Kim, Y H; Kim, H S; Hong, Y S; Ro, J S; Lee, K S; Lee, J J.
Afiliación
  • Hwang BY; Natural Product Biosynthesis Research Unit, Korea Research Institute of Bioscience, and Biotechnology, P.O. Box 115, Yusong, Taejon 305-600, Korea.
J Nat Prod ; 62(4): 640-3, 1999 Apr.
Article en En | MEDLINE | ID: mdl-10217732
The methanol-soluble extracts of the roots of Cynanchum wilfordii showed a significant multidrug-resistance-reversing activity, and four known pregnane glycosides were isolated by bioassay-directed fractionation and separation. Their structures were identified as gagaminin 3-O-beta-D-cymaropyranosyl-(1-->4)-beta-D-oleandropyranosyl- (1-->4)-b eta-D-cymaropyranosyl-(1-->4)-beta-D-cymaropyranoside (1), wilfoside K1N (2), wilfoside C1N (3), and cynauricuoside A (4). In particular, compound 1, at a concentration level of 1 microM, was found to completely reverse the multidrug-resistance of KB-V1 and MCF7/ADR cells to adriamycin, vinblastine, and colchicine.
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Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Plantas Medicinales / Pregnanos / Antineoplásicos Fitogénicos Límite: Humans Idioma: En Revista: J Nat Prod Año: 1999 Tipo del documento: Article Pais de publicación: Estados Unidos
Buscar en Google
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Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Plantas Medicinales / Pregnanos / Antineoplásicos Fitogénicos Límite: Humans Idioma: En Revista: J Nat Prod Año: 1999 Tipo del documento: Article Pais de publicación: Estados Unidos