Phosphorothioate oligodeoxyribonucleotides inhibit ribonuclease L thereby disabling a mechanism of interferon action.

Player, M R; Torrence, P F

Player, M R; Torrence, P F.

Afiliación

Player MR; Section on Biomedical Chemistry, Laboratory of Medicinal Chemistry, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD 20892-0805, USA.

Bioorg Med Chem Lett ; 9(6): 891-4, 1999 Mar 22.

Article en En | MEDLINE | ID: mdl-10206556

RESUMEN

Phosphorothioate oligodeoxyribonucleotides were found to be inhibitors of the 2-5A-dependent RNase L. Inhibitory potency depended upon the chain length of the phosphorothioate oligonucleotide and was dependent on the phosphorothioate substitution pattern, but was not substantially base-dependent.

Asunto(s)

Endorribonucleasas/antagonistas & inhibidores; Tionucleótidos/farmacología; Humanos; Concentración 50 Inhibidora; Modelos Químicos; Oligodesoxirribonucleótidos/síntesis química; Oligodesoxirribonucleótidos/química

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Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Tionucleótidos / Endorribonucleasas Límite: Humans Idioma: En Revista: Bioorg Med Chem Lett Asunto de la revista: BIOQUIMICA / QUIMICA Año: 1999 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Reino Unido

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