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Cellular response to DNA damage. Link between p53 and DNA-PK.
Salles-Passador, I; Fotedar, A; Fotedar, R.
Afiliación
  • Salles-Passador I; Institut de biologie structurale J.-P.-Ebel, Grenoble, France.
C R Acad Sci III ; 322(2-3): 113-20, 1999.
Article en En | MEDLINE | ID: mdl-10196661
Cells which lack DNA-activated protein kinase (DNA-PK) are very susceptible to ionizing radiation and display an inability to repair double strand DNA breaks. DNA-PK is a member of a protein kinase family that includes ATR and ATM which have strong homology in their carboxy-terminal kinase domain with PL-3 kinase. ATM has been proposed to act upstream of p53 in cellular response to ionizing radiation. DNA-PK may similarly interact with p53 in cellular growth control and in mediation of the response to ionizing radiation.
Asunto(s)
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Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Daño del ADN / Células / Genes p53 / Proteínas Serina-Treonina Quinasas Límite: Animals / Humans Idioma: En Revista: C R Acad Sci III Asunto de la revista: BIOLOGIA Año: 1999 Tipo del documento: Article País de afiliación: Francia Pais de publicación: Francia
Buscar en Google
Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Daño del ADN / Células / Genes p53 / Proteínas Serina-Treonina Quinasas Límite: Animals / Humans Idioma: En Revista: C R Acad Sci III Asunto de la revista: BIOLOGIA Año: 1999 Tipo del documento: Article País de afiliación: Francia Pais de publicación: Francia