Cellular response to DNA damage. Link between p53 and DNA-PK.
C R Acad Sci III
; 322(2-3): 113-20, 1999.
Article
en En
| MEDLINE
| ID: mdl-10196661
Cells which lack DNA-activated protein kinase (DNA-PK) are very susceptible to ionizing radiation and display an inability to repair double strand DNA breaks. DNA-PK is a member of a protein kinase family that includes ATR and ATM which have strong homology in their carboxy-terminal kinase domain with PL-3 kinase. ATM has been proposed to act upstream of p53 in cellular response to ionizing radiation. DNA-PK may similarly interact with p53 in cellular growth control and in mediation of the response to ionizing radiation.
Buscar en Google
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Daño del ADN
/
Células
/
Genes p53
/
Proteínas Serina-Treonina Quinasas
Límite:
Animals
/
Humans
Idioma:
En
Revista:
C R Acad Sci III
Asunto de la revista:
BIOLOGIA
Año:
1999
Tipo del documento:
Article
País de afiliación:
Francia
Pais de publicación:
Francia