M6P/IGFII-receptor complexes urokinase receptor and plasminogen for activation of transforming growth factor-beta1.

Godár, S; Horejsi, V; Weidle, U H; Binder, B R; Hansmann, C; Stockinger, H

Godár, S; Horejsi, V; Weidle, U H; Binder, B R; Hansmann, C; Stockinger, H.

Afiliación

Godár S; Institute of Immunology, Vienna International Research Cooperation Center at NFI, University of Vienna, Austria.

Eur J Immunol ; 29(3): 1004-13, 1999 03.

Article en En | MEDLINE | ID: mdl-10092105

RESUMEN

Transforming growth factor-beta1 (TGF-beta1) is a critical cytokine for cell proliferation and differentiation. It is secreted by many cells in a latent pro-form (LTGF-beta1) from which biologically active TGF-beta1 is released by an in vivo mechanism that is not known. Here we show that the mannose-6-phosphate/insulin-like growth factor II-receptor (M6P/IGFII-R), which binds LTGF-beta1, complexes with urokinase (plasminogen activator)-receptor (uPA-R) on the surface of human monocytes and directly binds plasminogen (Plg). Plasmin generated from Plg in the complex mediates release of TGF-beta1 when M6P/IGFII-R is associated with uPA-R. Thus, this interaction of M6P/IGFII-R and uPA-R suggests a potential mechanism for the generation of TGF-beta1 by cells.

Asunto(s)

Plasminógeno/metabolismo; Receptor IGF Tipo 2/metabolismo; Receptores de Superficie Celular/metabolismo; Factor de Crecimiento Transformador beta/metabolismo; Secuencia de Aminoácidos; Fibrinolisina/metabolismo; Humanos; Datos de Secuencia Molecular; Receptores del Activador de Plasminógeno Tipo Uroquinasa

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Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Plasminógeno / Factor de Crecimiento Transformador beta / Receptor IGF Tipo 2 / Receptores de Superficie Celular Límite: Humans Idioma: En Revista: Eur J Immunol Año: 1999 Tipo del documento: Article País de afiliación: Austria Pais de publicación: Alemania

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