Studies on arylfuran derivatives. Part VII. Synthesis and characterization of some Mannich bases carrying halophenylfuryl moieties as promising antibacterial agents.

Holla, B S; Shivananda, M K; Shenoy, M S; Antony, G

Holla, B S; Shivananda, M K; Shenoy, M S; Antony, G.

Afiliación

Holla BS; Department of Chemistry, Mangalore University, Mangalagangotri, India. root@mnglr.ernet.in

Farmaco ; 53(8-9): 531-5, 1998.

Article en En | MEDLINE | ID: mdl-10081814

RESUMEN

A series of 4-[5-(halophenyl)-2-furfurylidene)] amino-3-mercapto-5-substituted-1,2,4-triazoles (3) were synthesized. Aminomethylation of 3 with formaldehyde and a secondary amine furnished Mannich bases, 4. Both Schiff bases and Mannich bases were characterized on the basis of IR, NMR, mass spectral data and elemental analysis. All the newly synthesized compounds were tested for their antibacterial activities. Some of them carrying morpholino and N-methylpiperazino residues were found to be promising antibacterial agents.

Asunto(s)

Antibacterianos/síntesis química; Furanos/síntesis química; Antibacterianos/química; Antibacterianos/farmacología; Bacillus subtilis/efectos de los fármacos; Escherichia coli/efectos de los fármacos; Furanos/química; Furanos/farmacología; Pruebas de Sensibilidad Microbiana; Pseudomonas aeruginosa/efectos de los fármacos; Análisis Espectral; Staphylococcus aureus/efectos de los fármacos

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Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Furanos / Antibacterianos Idioma: En Revista: Farmaco Asunto de la revista: FARMACOLOGIA / QUIMICA Año: 1998 Tipo del documento: Article País de afiliación: India Pais de publicación: Francia

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