Effect of an angiotensin II receptor antagonist, candesartan, on insulin resistance and pressor mechanisms in essential hypertension.
J Hum Hypertens
; 13 Suppl 1: S71-4, 1999 Jan.
Article
en En
| MEDLINE
| ID: mdl-10076924
Candesartan (8 mg/d) was administered for 2 weeks to eight patients with essential hypertension to investigate the effect of an angiotensin II receptor antagonist on insulin sensitivity. The effect of candesartan on sodium-retaining action and the activation of pressor systems by hyperinsulinaemia, which might be related to pressor mechanisms in essential hypertension, was also investigated in this study. In patients with essential hypertension, candesartan restored insulin sensitivity to the level of that in normotensive subjects. Candesartan treatment attenuated the sodium-retaining action of hyperinsulinaemia. These findings suggest that inhibition of angiotensin II action by candesartan can improve insulin sensitivity and inhibit the sodium-retaining action associated with hyperinsulinaemia in essential hypertension.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Tetrazoles
/
Bencimidazoles
/
Presión Sanguínea
/
Resistencia a la Insulina
/
Antagonistas de Receptores de Angiotensina
/
Hipertensión
/
Antihipertensivos
Tipo de estudio:
Etiology_studies
/
Observational_studies
/
Prognostic_studies
/
Risk_factors_studies
Límite:
Humans
/
Middle aged
Idioma:
En
Revista:
J Hum Hypertens
Asunto de la revista:
ANGIOLOGIA
Año:
1999
Tipo del documento:
Article
País de afiliación:
Japón
Pais de publicación:
Reino Unido