Exon shuffling by L1 retrotransposition.
Science
; 283(5407): 1530-4, 1999 Mar 05.
Article
en En
| MEDLINE
| ID: mdl-10066175
Long interspersed nuclear elements (LINE-1s or L1s) are the most abundant retrotransposons in the human genome, and they serve as major sources of reverse transcriptase activity. Engineered L1s retrotranspose at high frequency in cultured human cells. Here it is shown that L1s insert into transcribed genes and retrotranspose sequences derived from their 3' flanks to new genomic locations. Thus, retrotransposition-competent L1s provide a vehicle to mobilize non-L1 sequences, such as exons or promoters, into existing genes and may represent a general mechanism for the evolution of new genes.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Recombinación Genética
/
Genoma Humano
/
Exones
/
Elementos de Nucleótido Esparcido Largo
Límite:
Humans
Idioma:
En
Revista:
Science
Año:
1999
Tipo del documento:
Article
Pais de publicación:
Estados Unidos