[A case of hyalinizing spindle cell tumor with giant rosettes in the presacral region. Immunohistochemical and ultrastructural study]. / Un cas de tumeur à cellules fusiformes hyalinisante avec rosettes géantes de la région présacrée. Etude immunohistochimique et ultrastructurale.
Ann Pathol
; 18(6): 488-91, 1998 Dec.
Article
en Fr
| MEDLINE
| ID: mdl-10051917
Hyalinizing spindle cell tumor with giant rosettes is a slowly growing tumor with a risk of local recurrence in case of incomplete surgical excision that could be regarded as a distinctive type of low-grade fibroblastic tumor. We report a case involving the presacral area. This tumor was composed of areas of bland spindle cell proliferation with a fascicular pattern in a fibrous or myxoid stroma, intermixed with giant rosettes consisting of rounded cells surrounding a central collagen core. The tumor expressed vimentin, and, for cells comprising the rosettes, S-100 protein, NSE and CD-57. These latter cells exhibited ultrastructural features of Schwann cells, the tumoral cells of fascicular area exhibiting features of fibroblastic cells. Flow cytometry showed DNA-aneuploidy and a very low S-phase fraction. This tumor appeared to be composed of two cellular components, fibroblastic and Schwann cells, located, at the opposite of neurofibroma, in two distinct areas.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Sacro
/
Neoplasias de los Tejidos Blandos
/
Inmunohistoquímica
/
Microscopía Electrónica
Límite:
Humans
/
Male
/
Middle aged
Idioma:
Fr
Revista:
Ann Pathol
Año:
1998
Tipo del documento:
Article
País de afiliación:
Francia
Pais de publicación:
Francia