Penetration of meropenem in lung, bronchial mucosa, and pleural tissues.

Byl, B; Jacobs, F; Roucloux, I; de Franquen, P; Cappello, M; Thys, J P

Byl, B; Jacobs, F; Roucloux, I; de Franquen, P; Cappello, M; Thys, J P.

Afiliación

Byl B; Infectious Diseases Clinic, Erasme Hospital, Université Libre de Bruxelles, Belgium. baudouin.byl@ulb.ac.be

Antimicrob Agents Chemother ; 43(3): 681-2, 1999 Mar.

Article en En | MEDLINE | ID: mdl-10049288

RESUMEN

Lung, bronchial mucosa, and pleural tissue samples were obtained from 14 patients undergoing lung surgery 1 to 5 h after administration of 1 g of meropenem. The mean (range) peak concentrations of meropenem were 3.9 (0.2 to 8.2), 6.6 (3.0 to 13.3), and 2.8 (0.6 to 7.8) mg/kg of tissue, respectively, exceeding the MICs at which 90% of isolates are inhibited for most respiratory pathogens.

Asunto(s)

Bronquios/metabolismo; Pulmón/metabolismo; Pleura/metabolismo; Tienamicinas/farmacocinética; Adulto; Anciano; Semivida; Humanos; Meropenem; Persona de Mediana Edad; Membrana Mucosa/metabolismo; Distribución Tisular

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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Pleura / Bronquios / Tienamicinas / Pulmón Límite: Adult / Aged / Humans / Middle aged Idioma: En Revista: Antimicrob Agents Chemother Año: 1999 Tipo del documento: Article País de afiliación: Bélgica Pais de publicación: Estados Unidos

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