Cat peripheral nerve regeneration across 50 mm gap repaired with a novel nerve guide composed of freeze-dried alginate gel.
Neurosci Lett
; 259(2): 75-8, 1999 Jan 08.
Article
en En
| MEDLINE
| ID: mdl-10025561
We have developed a novel artificial nerve guide composed of biodegradable freeze-dried alginate gel covered by polyglycolic acid mesh, and evaluated its effect on peripheral nerve regeneration, using a 50-mm gap cat sciatic nerve model. Functional reinnervation of motor and sensory nerves occurred 13 weeks after implantation, as demonstrated by recovery of compound muscle action potential (CMAP) and somatosensory evoked potential (SEP). For histologic evaluation, samples of tissue were harvested from the grafted material segment 7 months after operation. Many newly developed nerve fasciculi were found, and the implanted nerve guidance material had completely disappeared with little inflammation. These results indicate that freeze-dried alginate gel allows the nerve to regenerate across longer gaps than described in previous literature.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Nervios Periféricos
/
Implantes Experimentales
/
Alginatos
/
Regeneración Nerviosa
Límite:
Animals
Idioma:
En
Revista:
Neurosci Lett
Año:
1999
Tipo del documento:
Article
País de afiliación:
Japón
Pais de publicación:
Irlanda