Substance P injected into the medial preoptic area inhibits sodium, potassium and water urinary excretion: putative modulation of the cholinergic system
Braz. j. med. biol. res
; 22(7): 895-9, 1989. ilus
Article
en En
| LILACS
| ID: lil-83287
Biblioteca responsable:
BR26.1
ABSTRACT
Substance P (SP, 1.5 nmol) injected into the medial preoptic area (MPOA) of conscious, unrestrained, water-loaded male rats induced a significant decrease in urinary sodium, potassium and water excretion. In contrast, a significant natriuretic effect was observed after injection of 0.3 nmol of a specific competitive SP antagonist ([D-Pr**2, D-Trp**7,**9]-substance P). SP partially blocked the carbachol-induced natriuresis in a time-dependent manner. These data indicate a tonic inhibitory action of SP on sodium excretion and suggest a putative modulatory action of SP on the cholinergic system
Buscar en Google
Colección:
01-internacional
Base de datos:
LILACS
Asunto principal:
Potasio
/
Área Preóptica
/
Sodio
/
Agua
/
Sustancia P
Límite:
Animals
Idioma:
En
Revista:
Braz. j. med. biol. res
Asunto de la revista:
BIOLOGIA
/
MEDICINA
Año:
1989
Tipo del documento:
Article
/
Congress and conference
/
Project document
Pais de publicación:
Brasil