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Assessment of indicators of vitamin A status in non-cirrhotic chronic hepatitis C patients
Santana, R.C.; Machado, A.A.; Martinelli, A.L.C.; Jordão, A.A.; Ramalho, L.N.Z.; Vannucchi, H..
Afiliación
  • Santana, R.C.; Universidade de São Paulo. Hospital das Clínicas, Faculdade de Medicina de Ribeirão Preto. Departamento de Clínica Médica. Divisão de Infectologia. Ribeirão Preto. BR
  • Machado, A.A.; Universidade de São Paulo. Hospital das Clínicas, Faculdade de Medicina de Ribeirão Preto. Departamento de Clínica Médica. Divisão de Infectologia. Ribeirão Preto. BR
  • Martinelli, A.L.C.; Universidade de São Paulo. Hospital das Clínicas, Faculdade de Medicina de Ribeirão Preto. Departamento de Clínica Médica. Divisão de Infectologia. Ribeirão Preto. BR
  • Jordão, A.A.; Universidade de São Paulo. Hospital das Clínicas, Faculdade de Medicina de Ribeirão Preto. Departamento de Clínica Médica. Divisão de Infectologia. Ribeirão Preto. BR
  • Ramalho, L.N.Z.; Universidade de São Paulo. Hospital das Clínicas, Faculdade de Medicina de Ribeirão Preto. Departamento de Clínica Médica. Divisão de Infectologia. Ribeirão Preto. BR
  • Vannucchi, H.; Universidade de São Paulo. Hospital das Clínicas, Faculdade de Medicina de Ribeirão Preto. Departamento de Clínica Médica. Divisão de Infectologia. Ribeirão Preto. BR
Rev. bras. pesqui. méd. biol ; Braz. j. med. biol. res;49(1): 00702, 2016. tab, graf
Article en En | LILACS | ID: lil-765005
Biblioteca responsable: BR1.1
ABSTRACT
Subjects with chronic liver disease are susceptible to hypovitaminosis A due to several factors. Therefore, identifying patients with vitamin deficiency and a requirement for vitamin supplementation is important. Most studies assessing vitamin A in the context of hepatic disorders are conducted using cirrhotic patients. A cross-sectional study was conducted in 43 non-cirrhotic patients with chronic hepatitis C to evaluate markers of vitamin A status represented by serum retinol, liver retinol, and serum retinol-binding protein levels. We also performed the relative dose-response test, which provides an indirect estimate of hepatic vitamin A reserves. These vitamin A indicators were assessed according to the stage of liver fibrosis using the METAVIR score and the body mass index. The sample study was predominantly composed of male subjects (63%) with mild liver fibrosis (F1). The relative dose-response test was <20% in all subjects, indicating vitamin A sufficiency. Overweight or obese patients had higher serum retinol levels than those with a normal body mass index (2.6 and 1.9 µmol/L, respectively; P<0.01). Subjects with moderate liver fibrosis (F2) showed lower levels of serum retinol (1.9 vs 2.5 µmol/L, P=0.01) and retinol-binding protein levels compared with those with mild fibrosis (F1) (46.3 vs 67.7 µg/mL, P<0.01). These results suggested an effect of being overweight on serum retinol levels. Furthermore, more advanced stages of liver fibrosis were related to a decrease in serum vitamin A levels.
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Texto completo: 1 Colección: 01-internacional Base de datos: LILACS Asunto principal: Vitamina A / Deficiencia de Vitamina A / Hepatitis C Crónica Tipo de estudio: Observational_studies / Prevalence_studies / Prognostic_studies / Risk_factors_studies Límite: Adult / Aged / Female / Humans / Male Idioma: En Revista: Braz. j. med. biol. res / Rev. bras. pesqui. méd. biol Asunto de la revista: BIOLOGIA / MEDICINA Año: 2016 Tipo del documento: Article País de afiliación: Brasil Pais de publicación: Brasil
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Texto completo: 1 Colección: 01-internacional Base de datos: LILACS Asunto principal: Vitamina A / Deficiencia de Vitamina A / Hepatitis C Crónica Tipo de estudio: Observational_studies / Prevalence_studies / Prognostic_studies / Risk_factors_studies Límite: Adult / Aged / Female / Humans / Male Idioma: En Revista: Braz. j. med. biol. res / Rev. bras. pesqui. méd. biol Asunto de la revista: BIOLOGIA / MEDICINA Año: 2016 Tipo del documento: Article País de afiliación: Brasil Pais de publicación: Brasil