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HIV-1 epidemiology and circulating subtypes in the countryside of South Brazil
Librelotto, Carina Sperotto; Gräf, Tiago; Simon, Daniel; Almeida, Sabrina Esteves Matos de; Lunge, Vagner Ricardo.
Afiliación
  • Librelotto, Carina Sperotto; Universidade Luterana do Brasil. Programa de Pós-Graduação em Biologia Celular e Molecular Aplicada à Saúde. Canoas. BR
  • Gräf, Tiago; Universidade Luterana do Brasil. Programa de Pós-Graduação em Biologia Celular e Molecular Aplicada à Saúde. Canoas. BR
  • Simon, Daniel; Universidade Luterana do Brasil. Programa de Pós-Graduação em Biologia Celular e Molecular Aplicada à Saúde. Canoas. BR
  • Almeida, Sabrina Esteves Matos de; Universidade Luterana do Brasil. Programa de Pós-Graduação em Biologia Celular e Molecular Aplicada à Saúde. Canoas. BR
  • Lunge, Vagner Ricardo; Universidade Luterana do Brasil. Programa de Pós-Graduação em Biologia Celular e Molecular Aplicada à Saúde. Canoas. BR
Rev. Soc. Bras. Med. Trop ; 48(3): 249-257, May-Jun/2015. tab, graf
Article en En | LILACS | ID: lil-749868
Biblioteca responsable: BR1.1
ABSTRACT

INTRODUCTION:

Human immunodeficiency virus type 1 (HIV-1) has spread worldwide, with several subtypes and circulating recombinant forms. Brazil has an incidence of 20.5 HIV-1/acquired immunodeficiency syndrome (AIDS) patients per 100,000 inhabitants; however, the Southernmost State of Rio Grande do Sul (RS) has more than twice the number of HIV-1-infected people (41.3/100,000 inhabitants) and a different pattern of subtype frequencies, as previously reported in studies conducted in the capital (Porto Alegre) and its metropolitan region. This study examined HIV-1/AIDS epidemiological and molecular aspects in the countryside of Rio Grande do Sul.

METHODS:

Socio-demographic, clinical and risk behavioral characteristics were obtained from HIV-1-positive adult patients using a structured questionnaire. HIV-1 subtypes were determined by nested-polymerase chain reaction (PCR) and sequencing of the pol and env genes.

RESULTS:

The study sample included 149 (55% women) patients with a mean age of 41.8 ± 11.9 years. Most (73.8%) patients had a low education level and reported heterosexual practices as the most (91.9%) probable transmission route. HIV-1 subtypes were detected in 26 patients 18 (69.2%) infected with subtype C, six (23.1%) infected with subtype B and two (7.7%) infected with BC recombinant forms.

CONCLUSIONS:

These data highlight the increasing number of HIV-1 subtype C infections in the countryside of South Brazil. .
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Texto completo: 1 Colección: 01-internacional Base de datos: LILACS Asunto principal: Infecciones por VIH / VIH-1 Tipo de estudio: Etiology_studies / Observational_studies / Prevalence_studies / Qualitative_research / Risk_factors_studies / Screening_studies Límite: Adult / Female / Humans / Male País/Región como asunto: America do sul / Brasil Idioma: En Revista: Rev. Soc. Bras. Med. Trop Asunto de la revista: MEDICINA TROPICAL Año: 2015 Tipo del documento: Article País de afiliación: Brasil Pais de publicación: Brasil
Texto completo
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Imprimir
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Texto completo: 1 Colección: 01-internacional Base de datos: LILACS Asunto principal: Infecciones por VIH / VIH-1 Tipo de estudio: Etiology_studies / Observational_studies / Prevalence_studies / Qualitative_research / Risk_factors_studies / Screening_studies Límite: Adult / Female / Humans / Male País/Región como asunto: America do sul / Brasil Idioma: En Revista: Rev. Soc. Bras. Med. Trop Asunto de la revista: MEDICINA TROPICAL Año: 2015 Tipo del documento: Article País de afiliación: Brasil Pais de publicación: Brasil