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Tuberculosis in HIV-infected infants, children, and adolescents in Latin America
Krauss, Margot R.; Harris, D. Robert; Abreu, Thalita; Ferreira, Fabiana G.; Ruz, Noris Pavia; Worrell, Carol; Hazra, Rohan; for the NISDI Pediatric Study Group.
Afiliación
  • Krauss, Margot R.; Westat. Rockville. US
  • Harris, D. Robert; Westat. Rockville. US
  • Abreu, Thalita; Westat. Rockville. US
  • Ferreira, Fabiana G.; Westat. Rockville. US
  • Ruz, Noris Pavia; Westat. Rockville. US
  • Worrell, Carol; Westat. Rockville. US
  • Hazra, Rohan; Westat. Rockville. US
Braz. j. infect. dis ; 19(1): 23-29, Jan-Feb/2015. tab, graf
Article en En | LILACS | ID: lil-741228
Biblioteca responsable: BR1.1
ABSTRACT

Objective:

To evaluate the occurrence, clinical presentations and diagnostic methods for tuberculosis in a cohort of HIV-infected infants, children and adolescents from Latin America.

Methods:

A retrospective analysis of children with tuberculosis and HIV was performed within a prospective observational cohort study conducted at multiple clinical sites in Latin America.

Results:

Of 1114 HIV-infected infants, children, and adolescents followed from 2002 to 2011, 69 that could be classified as having confirmed or presumed tuberculosis were included in this case series; 52.2% (95% CI 39.8-64.4%) had laboratory-confirmed tuberculosis, 15.9% (95% CI 8.2-26.7%) had clinically confirmed disease and 31.9% (95% CI 21.2-44.2%) had presumed tuberculosis. Sixty-six were perinatally HIV-infected. Thirty-two (61.5%) children had a history of contact with an adult tuberculosis case; however information on exposure to active tuberculosis was missing for 17 participants. At the time of tuberculosis diagnosis, 39 were receiving antiretroviral therapy. Sixteen of these cases may have represented immune reconstitution inflammatory syndrome.

Conclusions:

Our study emphasizes the need for adequate contact tracing of adult tuberculosis cases and screening for HIV or tuberculosis in Latin American children diagnosed with either condition. Preventive strategies in tuberculosis-exposed, HIV-infected children should be optimized. .
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Texto completo: 1 Colección: 01-internacional Base de datos: LILACS Asunto principal: Tuberculosis Pulmonar / Infecciones Oportunistas Relacionadas con el SIDA Tipo de estudio: Diagnostic_studies / Etiology_studies / Observational_studies / Risk_factors_studies Límite: Adolescent / Child / Child, preschool / Female / Humans / Infant / Male / Newborn Idioma: En Revista: Braz. j. infect. dis Asunto de la revista: DOENCAS TRANSMISSIVEIS Año: 2015 Tipo del documento: Article / Project document País de afiliación: Estados Unidos Pais de publicación: Brasil
Texto completo
Añadir a Mi BVS
Imprimir
XML
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Texto completo: 1 Colección: 01-internacional Base de datos: LILACS Asunto principal: Tuberculosis Pulmonar / Infecciones Oportunistas Relacionadas con el SIDA Tipo de estudio: Diagnostic_studies / Etiology_studies / Observational_studies / Risk_factors_studies Límite: Adolescent / Child / Child, preschool / Female / Humans / Infant / Male / Newborn Idioma: En Revista: Braz. j. infect. dis Asunto de la revista: DOENCAS TRANSMISSIVEIS Año: 2015 Tipo del documento: Article / Project document País de afiliación: Estados Unidos Pais de publicación: Brasil