Copaiba oil effect under different pathways in mice subjected to sepsis
Acta cir. bras
; Acta cir. bras;29(8): 528-531, 08/2014. tab, graf
Article
en En
| LILACS
| ID: lil-719181
Biblioteca responsable:
BR1.1
ABSTRACT
PURPOSE:
To evaluate the effects of copaiba oil administered by different routes on survival of mices subjected to cecal ligation and puncture.METHODS:
Thirty two mice were distributed into four study groups (N=8) Sham group normal standard animals; Control group submitted a cecal ligation and puncture (CLP); Gavage group submitted a CLP, and treat with copaiba oil by gavage; and Subcutaneous group submitted a CLP, and treat with copaiba oil by subcutaneous injection. After the death of the histological analysis were performed. The Kaplan-Meier curves of surviving time were realized.RESULTS:
All animals that received copaiba, regardless of the route used, survived longer when compared to the control group (p<0.0001), whereas the survival time ranged from 20 hours for the control group up to 32 hours for the animals of gavage group and 52 for subcutaneous group. The animals that received gavage copaiba lived about and about 20 hours unless the subcutaneous group (p=0.0042). There was no statistical difference when compared the intensity of inflammatory response (p>0.05)CONCLUSION:
Prophylactic subcutaneous administration of copaiba in mice subjected to severe sepsis by cecal ligation and puncture, resulted in a survival time higher than non-use or use of this oil by gavage. .Palabras clave
Texto completo:
1
Colección:
01-internacional
Base de datos:
LILACS
Asunto principal:
Bálsamos
/
Sepsis
Tipo de estudio:
Prognostic_studies
Límite:
Animals
Idioma:
En
Revista:
Acta cir. bras
Asunto de la revista:
Cirurgia Geral
/
Procedimentos Cir£rgicos Operat¢rios
Año:
2014
Tipo del documento:
Article
País de afiliación:
Brasil
Pais de publicación:
Brasil