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Imbalanced expression of functional surface molecules in regulatory and effector T cells in systemic lupus erythematosus
Mesquita Júnior, D.; Cruvinel, W.M.; Araujo, J.A.P.; Salmazi, K.C.; Kallas, E.G.; Andrade, L.E.C..
Afiliación
  • Mesquita Júnior, D.; Universidade Federal de São Paulo. Escola Paulista de Medicina. Departamento de Medicina. Disciplina de Reumatologia. São Paulo. BR
  • Cruvinel, W.M.; Universidade Federal de São Paulo. Escola Paulista de Medicina. Departamento de Medicina. Disciplina de Reumatologia. São Paulo. BR
  • Araujo, J.A.P.; Universidade Federal de São Paulo. Escola Paulista de Medicina. Departamento de Medicina. Disciplina de Reumatologia. São Paulo. BR
  • Salmazi, K.C.; Universidade Federal de São Paulo. Escola Paulista de Medicina. Departamento de Medicina. Disciplina de Reumatologia. São Paulo. BR
  • Kallas, E.G.; Universidade Federal de São Paulo. Escola Paulista de Medicina. Departamento de Medicina. Disciplina de Reumatologia. São Paulo. BR
  • Andrade, L.E.C.; Universidade Federal de São Paulo. Escola Paulista de Medicina. Departamento de Medicina. Disciplina de Reumatologia. São Paulo. BR
Rev. bras. pesqui. méd. biol ; Braz. j. med. biol. res;47(8): 662-669, 08/2014. tab, graf
Article en En | LILACS | ID: lil-716275
Biblioteca responsable: BR1.1
ABSTRACT
Regulatory T (TREG) cells play an important role in maintaining immune tolerance and avoiding autoimmunity. We analyzed the expression of membrane molecules in TREG and effector T cells in systemic lupus erythematosus (SLE). TREG and effector T cells were analyzed for the expression of CTLA-4, PD1, CD28, CD95, GITR, HLA-DR, OX40, CD40L, and CD45RO in 26 patients with active disease, 31 with inactive disease, and 26 healthy controls. TREG cells were defined as CD25+/highCD127Ø/lowFoxP3+, and effector T cells were defined as CD25+CD127+FoxP3Ø. The ratio of TREG to effector T cells expressing GITR, PD1, HLA-DR, OX40, CD40L, and CD45RO was determined in the three groups. The frequency of TREG cells was similar in patients with SLE and controls. However, SLE patients had a decreased frequency of CTLA-4+TREG and CD28+TREG cells and an increased frequency of CD40L+TREG cells. There was a decrease in the TREG/effector-T ratio for GITR+, HLA-DR+, OX40+, and CD45RO+ cells, and an increased ratio of TREG/effector-T CD40L+ cells in patients with SLE. In addition, CD40L+TREG cell frequency correlated with the SLE disease activity index (P=0.0163). In conclusion, our findings showed several abnormalities in the expression of functionally critical surface molecules in TREG and effector T cells in SLE that may be relevant to the pathogenesis of this disease.
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Texto completo: 1 Colección: 01-internacional Base de datos: LILACS Asunto principal: Leucocitos Mononucleares / Linfocitos T Reguladores / Lupus Eritematoso Sistémico / Antígenos de Superficie Límite: Adult / Female / Humans / Male Idioma: En Revista: Braz. j. med. biol. res / Rev. bras. pesqui. méd. biol Asunto de la revista: BIOLOGIA / MEDICINA Año: 2014 Tipo del documento: Article / Project document País de afiliación: Brasil Pais de publicación: Brasil
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Texto completo: 1 Colección: 01-internacional Base de datos: LILACS Asunto principal: Leucocitos Mononucleares / Linfocitos T Reguladores / Lupus Eritematoso Sistémico / Antígenos de Superficie Límite: Adult / Female / Humans / Male Idioma: En Revista: Braz. j. med. biol. res / Rev. bras. pesqui. méd. biol Asunto de la revista: BIOLOGIA / MEDICINA Año: 2014 Tipo del documento: Article / Project document País de afiliación: Brasil Pais de publicación: Brasil