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Evaluation of conjunctival bacterial flora in patients with Stevens-Johnson Syndrome
Frizon, Luciana; Araujo, Marilia Cavalcante; Andrade, Larissa; Yu, Maria Cecilia Zorat; Wakamatsu, Tais Hitomi; Hofling-Lima, Ana Luisa; Gomes, Jose Alvaro Pereira.
Afiliación
  • Frizon, Luciana; Federal University of Sao Paulo. Vision Institute. Ophthalmology Department. Sao Paulo. BR
  • Araujo, Marilia Cavalcante; Federal University of Sao Paulo. Vision Institute. Ophthalmology Department. Sao Paulo. BR
  • Andrade, Larissa; Federal University of Sao Paulo. Vision Institute. Ophthalmology Department. Sao Paulo. BR
  • Yu, Maria Cecilia Zorat; Federal University of Sao Paulo. Vision Institute. Ophthalmology Department. Sao Paulo. BR
  • Wakamatsu, Tais Hitomi; Federal University of Sao Paulo. Vision Institute. Ophthalmology Department. Sao Paulo. BR
  • Hofling-Lima, Ana Luisa; Federal University of Sao Paulo. Vision Institute. Ophthalmology Department. Sao Paulo. BR
  • Gomes, Jose Alvaro Pereira; Federal University of Sao Paulo. Vision Institute. Ophthalmology Department. Sao Paulo. BR
Clinics ; 69(3): 168-172, 3/2014. tab
Article en En | LILACS | ID: lil-703596
Biblioteca responsable: BR1.1
ABSTRACT

OBJECTIVE:

To determine the conjunctival bacterial flora present in patients with Stevens-Johnson syndrome.

METHODS:

A prospective study of the conjunctival bacterial flora was performed in 41 eyes of 22 patients with Stevens-Johnson syndrome. The information gathered included the patient's sex and age, the duration of disease, the cause of Stevens-Johnson syndrome, and treatments. Scrapings of the inferior conjunctival fornix were performed in both eyes. Fourteen days before scraping, the patients were asked to interrupt all topical medication and start using 0.5% nonpreserved methylcellulose. The microbiological evaluation included microorganism identification and determination of antibiotic sensitivity.

RESULTS:

Of 22 patients (41 eyes), 14 (64%) were females, and eight (36%) were males. The mean age was 33.2 years, and the mean duration of disease was 15.6 years. Visual acuity ranged from light perception to 20/25 (1.57 logMar). The treatment received by most patients consisted of tear substitutes, topical antibiotics, and contact lenses. Bacterial identification was positive in 39 eyes (95%) and negative in two eyes (5%). Gram-positive cocci accounted for 55.5% of the microorganisms, whereas gram-positive bacilli and gram-negative bacilli accounted for 19% and 25.5%, respectively. Half of the patients (54%) had multiple bacterial species in their flora, and only one bacterial species was identified in the other half. Resistant bacteria were isolated from four eyes. The antibiotic sensitivity results for the Streptococcus group showed the lowest sensitivity and the highest microbial resistance identified.

CONCLUSION:

Patients with Stevens-Johnson syndrome have a diverse conjunctival flora that includes many pathogenic species. .
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Texto completo: 1 Colección: 01-internacional Base de datos: LILACS Asunto principal: Síndrome de Stevens-Johnson / Conjuntiva / Bacterias Gramnegativas / Bacterias Grampositivas Tipo de estudio: Observational_studies Límite: Adolescent / Adult / Child / Female / Humans / Male Idioma: En Revista: Clinics Asunto de la revista: MEDICINA Año: 2014 Tipo del documento: Article País de afiliación: Brasil Pais de publicación: Brasil
Texto completo
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Imprimir
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Texto completo: 1 Colección: 01-internacional Base de datos: LILACS Asunto principal: Síndrome de Stevens-Johnson / Conjuntiva / Bacterias Gramnegativas / Bacterias Grampositivas Tipo de estudio: Observational_studies Límite: Adolescent / Adult / Child / Female / Humans / Male Idioma: En Revista: Clinics Asunto de la revista: MEDICINA Año: 2014 Tipo del documento: Article País de afiliación: Brasil Pais de publicación: Brasil