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The protective effect of aqueous extracts of roselle (Hibiscus sabdariffa L. UKMR-2) against red blood cell membrane oxidative stress in rats with streptozotocin-induced diabetes
Mohamed, Jamaludin; Shing, Saw Wuan; Idris, Muhd Hanis Md; Budin, Siti Balkis; Zainalabidin, Satirah.
Afiliación
  • Mohamed, Jamaludin; Universiti Kebangsaan Malaysia. Faculty of Health Sciences. School of Diagnostic & Applied Health Sciences. Programme of Biomedical Sciences, Jalan Raja Muda Aziz. Kuala Lumpur. MY
  • Shing, Saw Wuan; Universiti Kebangsaan Malaysia. Faculty of Health Sciences. School of Diagnostic & Applied Health Sciences. Programme of Biomedical Sciences, Jalan Raja Muda Aziz. Kuala Lumpur. MY
  • Idris, Muhd Hanis Md; Universiti Kebangsaan Malaysia. Faculty of Health Sciences. School of Diagnostic & Applied Health Sciences. Programme of Biomedical Sciences, Jalan Raja Muda Aziz. Kuala Lumpur. MY
  • Budin, Siti Balkis; Universiti Kebangsaan Malaysia. Faculty of Health Sciences. School of Diagnostic & Applied Health Sciences. Programme of Biomedical Sciences, Jalan Raja Muda Aziz. Kuala Lumpur. MY
  • Zainalabidin, Satirah; Universiti Kebangsaan Malaysia. Faculty of Health Sciences. School of Diagnostic & Applied Health Sciences. Programme of Biomedical Sciences, Jalan Raja Muda Aziz. Kuala Lumpur. MY
Clinics ; 68(10): 1358-1363, out. 2013. tab, graf
Article en En | LILACS | ID: lil-689976
Biblioteca responsable: BR1.1
ABSTRACT

OBJECTIVES:

The aim of this study was to investigate the protective effects of aqueous extracts of roselle (Hibiscus sabdariffa L. UKMR-2) against red blood cell (RBC) membrane oxidative stress in rats with streptozotocin-induced diabetes.

METHODS:

Forty male Sprague-Dawley rats weighing 230-250 g were randomly divided into four groups (n = 10 rats each) control group (N), roselle-treated control group, diabetic group, and roselle-treated diabetic group. Roselle was administered by force-feeding with aqueous extracts of roselle (100 mg/kg body weight) for 28 days.

RESULTS:

The results demonstrated that the malondialdehyde levels of the red blood cell membranes in the diabetic group were significantly higher than the levels in the roselle-treated control and roselle-treated diabetic groups. The protein carbonyl level was significantly higher in the roselle-treated diabetic group than in the roselle-treated control group but lower than that in the diabetic group. A significant increase in the red blood cell membrane superoxide dismutase enzyme was found in roselle-treated diabetic rats compared with roselle-treated control rats and diabetic rats. The total protein level of the red blood cell membrane, osmotic fragility, and red blood cell morphology were maintained.

CONCLUSION:

The present study demonstrates that aqueous extracts of roselle possess a protective effect against red blood cell membrane oxidative stress in rats with streptozotocin-induced diabetes. These data suggest that roselle can be used as a natural antioxidative supplement in the prevention of oxidative damage in diabetic patients. .
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Texto completo: 1 Colección: 01-internacional Base de datos: LILACS Asunto principal: Extractos Vegetales / Estrés Oxidativo / Hibiscus / Diabetes Mellitus Experimental / Membrana Eritrocítica Límite: Animals Idioma: En Revista: Clinics Asunto de la revista: MEDICINA Año: 2013 Tipo del documento: Article / Project document País de afiliación: Malasia Pais de publicación: Brasil
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: LILACS Asunto principal: Extractos Vegetales / Estrés Oxidativo / Hibiscus / Diabetes Mellitus Experimental / Membrana Eritrocítica Límite: Animals Idioma: En Revista: Clinics Asunto de la revista: MEDICINA Año: 2013 Tipo del documento: Article / Project document País de afiliación: Malasia Pais de publicación: Brasil