ROC trials update on prehospital hypertonic saline resuscitation in the aftermath of the US-Canadian trials
Clinics
; 68(6): 883-886, jun. 2013.
Article
en En
| LILACS
| ID: lil-676943
Biblioteca responsable:
BR1.1
ABSTRACT
The objectives of this review are to assess the current state of hypertonic saline as a prehospital resuscitation fluid in hypotensive trauma patients, particularly after the 3 major Resuscitation Outcomes Consortium trauma trials in the US and Canada were halted due to futility. Hemorrhage and traumatic brain injury are the leading causes of death in both military and civilian populations. Prehospital fluid resuscitation remains controversial in civilian trauma, but small-volume resuscitation with hypertonic fluids is of utility in military scenarios with prolonged or delayed evacuation times. A large body of pre-clinical and clinical literature has accumulated over the past 30 years on the hemodynamic and, most recently, the anti-inflammatory properties of hypertonic saline, alone or with dextran-70. This review assesses the current state of hypertonic fluid resuscitation in the aftermath of the failed Resuscitation Outcomes Consortium trials.
Palabras clave
Texto completo:
1
Colección:
01-internacional
Base de datos:
LILACS
Asunto principal:
Resucitación
/
Solución Salina Hipertónica
/
Ensayos Clínicos como Asunto
/
Servicios Médicos de Urgencia
Límite:
Humans
País/Región como asunto:
America do norte
Idioma:
En
Revista:
Clinics
Asunto de la revista:
MEDICINA
Año:
2013
Tipo del documento:
Article
País de afiliación:
Estados Unidos
Pais de publicación:
Brasil