Characterization of convulsions induced by a hexanic extract of Spilanthes acmella var. oleracea in rats
Braz. j. med. biol. res
; 22(1): 65-7, 1989. ilus, tab
Article
en En
| LILACS
| ID: lil-67483
Biblioteca responsable:
BR26.1
RESUMO
To characterize the convulsions induced by a hexanic extract of Spilanthes acmella var. oleracea, male Wistar rats were injected ip with 50 to 150 mg/kg of the extract and EEG and hehavior were observed for periods as long as 2 h. Following the lower doses (50 and 75 mg/kg) only minor behavioral changes such as grooming and wet dog shakes were observed. Higher doses (100 to 150 mg/kg) induced full tonic-clonic convulsions in a dose-dependent manner which were accompanied by typical electrographic seizures in the EEG. These results confirm that the hexane extract of Spilanthes acmella var. oleracea is able to induce generalized convulsions in rats and can be used as a tool in the development of new models of epilepsy
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Colección:
01-internacional
Base de datos:
LILACS
Asunto principal:
Convulsiones
/
Conducta Animal
/
Extractos Vegetales
Límite:
Animals
Idioma:
En
Revista:
Braz. j. med. biol. res
Asunto de la revista:
BIOLOGIA
/
MEDICINA
Año:
1989
Tipo del documento:
Article
/
Congress and conference
Pais de publicación:
Brasil