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An improved experimental model for peripheral neuropathy in rats
Brazilian Journal of Medical and Biological Research; Dias, Q.M.; Rossaneis, A.C.; Fais, R.S.; Prado, W.A..
Afiliación
  • Dias, Q.M.; Universidade de São Paulo. Faculdade de Medicina de Ribeirão Preto. Departamento de Farmacologia. Ribeirão Preto. BR
  • Rossaneis, A.C.; Universidade de São Paulo. Faculdade de Medicina de Ribeirão Preto. Departamento de Farmacologia. Ribeirão Preto. BR
  • Fais, R.S.; Universidade de São Paulo. Faculdade de Medicina de Ribeirão Preto. Departamento de Farmacologia. Ribeirão Preto. BR
  • Prado, W.A.; Universidade de São Paulo. Faculdade de Medicina de Ribeirão Preto. Departamento de Farmacologia. Ribeirão Preto. BR
Rev. bras. pesqui. méd. biol ; Braz. j. med. biol. res;46(3): 253-256, 15/mar. 2013. graf
Article en En | LILACS | ID: lil-670905
Biblioteca responsable: BR1.1
ABSTRACT
A modification of the Bennett and Xie chronic constriction injury model of peripheral painful neuropathy was developed in rats. Under tribromoethanol anesthesia, a single ligature with 100% cotton glace thread was placed around the right sciatic nerve proximal to its trifurcation. The change in the hind paw reflex threshold after mechanical stimulation observed with this modified model was compared to the change in threshold observed in rats subjected to the Bennett and Xie or the Kim and Chung spinal ligation models. The mechanical threshold was measured with an automated electronic von Frey apparatus 0, 2, 7, and 14 days after surgery, and this threshold was compared to that measured in sham rats. All injury models produced significant hyperalgesia in the operated hind limb. The modified model produced mean ± SD thresholds in g (19.98 ± 3.08, 14.98 ± 1.86, and 13.80 ± 1.00 at 2, 7, and 14 days after surgery, respectively) similar to those obtained with the spinal ligation model (20.03 ± 1.99, 13.46 ± 2.55, and 12.46 ± 2.38 at 2, 7, and 14 days after surgery, respectively), but less variable when compared to the Bennett and Xie model (21.20 ± 8.06, 18.61 ± 7.69, and 18.76 ± 6.46 at 2, 7, and 14 days after surgery, respectively). The modified method required less surgical skill than the spinal nerve ligation model.
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Texto completo: 1 Colección: 01-internacional Base de datos: LILACS Asunto principal: Nervio Ciático / Umbral del Dolor / Enfermedades del Sistema Nervioso Periférico Tipo de estudio: Etiology_studies / Prognostic_studies Límite: Animals Idioma: En Revista: Braz. j. med. biol. res / Rev. bras. pesqui. méd. biol Asunto de la revista: BIOLOGIA / MEDICINA Año: 2013 Tipo del documento: Article / Project document País de afiliación: Brasil Pais de publicación: Brasil
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: LILACS Asunto principal: Nervio Ciático / Umbral del Dolor / Enfermedades del Sistema Nervioso Periférico Tipo de estudio: Etiology_studies / Prognostic_studies Límite: Animals Idioma: En Revista: Braz. j. med. biol. res / Rev. bras. pesqui. méd. biol Asunto de la revista: BIOLOGIA / MEDICINA Año: 2013 Tipo del documento: Article / Project document País de afiliación: Brasil Pais de publicación: Brasil