Pseudorabies virus can be classified into five genotypes using partial sequences of UL44

Fonseca Junior, A A; Camargos, M F; Sales, M L; Heinemann, M B; Leite, R C; Reis, J K P

Fonseca Junior, A A; Camargos, M F; Sales, M L; Heinemann, M B; Leite, R C; Reis, J K P.

Afiliación

Fonseca Junior, A A; Ministério da Agricultura, Pecuária e Abastecimento. Laboratório Nacional Agropecuário. Pedro Leopoldo. BR
Camargos, M F; Ministério da Agricultura, Pecuária e Abastecimento. Laboratório Nacional Agropecuário. Pedro Leopoldo. BR
Sales, M L; Ministério da Agricultura, Pecuária e Abastecimento. Laboratório Nacional Agropecuário. Pedro Leopoldo. BR
Heinemann, M B; Universidade Federal de Minas Gerais. Escola de Veterinária. Laboratório de Retroviroses. Belo Horizonte. BR
Leite, R C; Universidade Federal de Minas Gerais. Escola de Veterinária. Laboratório de Retroviroses. Belo Horizonte. BR
Reis, J K P; Universidade Federal de Minas Gerais. Escola de Veterinária. Laboratório de Retroviroses. Belo Horizonte. BR

Braz. j. microbiol ; 43(4): 1632-1640, Oct.-Dec. 2012. ilus, tab

Article en En | LILACS | ID: lil-665851

Biblioteca responsable: BR32.1

ABSTRACT

ABSTRACT

Suid herpesvirus 1 (SuHV-1) is the causative agent of pseudorabies (PR), a disease of great importance due to the huge losses it causes in the swine industry. The aim of this study was to determine a method for genotyping SuHV-1 based on partial sequences of the gene coding for glycoprotein C (gC) and to elucidate the possible reasons for the variability of this region. A total of 109 gCsequences collected from GenBank were divided into five major groups after reconstruction of a phylogenetic tree by Bayesian inference. The analysis showed that a portion of gC (approximately 671 bp) is under selective pressure at various points that coincide with regions of protein disorder. It was also possible to divide SuHV-1 into five genotypes that evolved under different selective pressures. These genotypes are not specific to countries or continents, perhaps due to multiple introduction events related to the importation of swine.

Asunto(s)

Animales; Variación Genética; Glicoproteínas/genética; Herpesvirus Suido 1/genética; Herpesvirus Suido 1/patogenicidad; Seudorrabia/genética; Secuencia de Bases/genética; Varicellovirus/genética; Varicellovirus/patogenicidad; Genética Microbiana; Genotipo; Métodos; Virulencia

Palabras clave

Bioinformatics; Glycoprotein; Pseudorabies

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Texto completo: 1 Colección: 01-internacional Base de datos: LILACS Asunto principal: Seudorrabia / Variación Genética / Secuencia de Bases / Glicoproteínas / Varicellovirus / Herpesvirus Suido 1 Límite: Animals Idioma: En Revista: Braz. j. microbiol Asunto de la revista: MICROBIOLOGIA Año: 2012 Tipo del documento: Article País de afiliación: Brasil Pais de publicación: Brasil

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