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Detection of Helicobacter pylori in gastric biopsies, saliva and dental plaques of dyspeptic patients from Marília, São Paulo, Brazil: presence of vacA and cagA genes
Rasmussen, L. T; Labio, R. W de; C Neto, A; Silva, L. C; Queiroz, V. F; Smith, M. A. C; Payão, S. L. M.
Afiliación
  • Rasmussen, L. T; Sacred Heart University. Bauru. BR
  • Labio, R. W de; Marília Medical School. Blood Center. Department of Genetics. Marília. BR
  • C Neto, A; Marília Medical School. Blood Center. Department of Genetics. Marília. BR
  • Silva, L. C; Marília Medical School. Department of Anatomic Pathology. Marília. BR
  • Queiroz, V. F; Marília Medical School. Department of Digestive System Surgery. Marília. BR
  • Smith, M. A. C; Federal University of São Paulo. Department of Morphology. São Paulo. BR
  • Payão, S. L. M; Sacred Heart University. Bauru. BR
J. venom. anim. toxins incl. trop. dis ; J. venom. anim. toxins incl. trop. dis;18(2): 180-187, 2012. tab
Article en En | LILACS, VETINDEX | ID: lil-639477
Biblioteca responsable: BR68.1
ABSTRACT
Helicobacter pylori, a gram-negative bacterium, possesses two important virulence factors the vacuolating toxin (vacA), and the cytotoxin-associated gene product (cagA). The aim of the present study was to evaluate the presence of H. pylori in the stomach and oral cavity of humans and compare the cagA and vacA genotypes of H. pylori found in different samples (stomach, saliva and dental plaque) from the same patient. Gastric biopsies, saliva and dental plaques were obtained from 62 dyspeptic adults. DNA was extracted and evaluated for the presence of H. pylori and the alleles cagA and vacA. Persons with gastritis had a higher frequency of H. pylori -positive samples in the stomach while positive samples from gastric biopsies were significantly correlated with those from the oral cavity. There was a high H. pylori frequency in patients while the cagA gene was associated with vacA s1 alleles in gastric biopsies. Our results suggest a reservoir of the species in the oral cavity and that, in one patient, more than one H. pylori strain may exist in the saliva, dental plaque and stomach. We found a relationship between gastric infection and the bacterium in the oral cavity, with the cytotoxin genotype varying between saliva and dental plaque.(AU)
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Texto completo: 1 Colección: 01-internacional Base de datos: LILACS / VETINDEX Asunto principal: Biopsia / Helicobacter pylori / Infecciones por Helicobacter Tipo de estudio: Diagnostic_studies Límite: Humans País/Región como asunto: America do sul / Brasil Idioma: En Revista: J. venom. anim. toxins incl. trop. dis Asunto de la revista: TOXICOLOGIA Año: 2012 Tipo del documento: Article País de afiliación: Brasil Pais de publicación: Brasil
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: LILACS / VETINDEX Asunto principal: Biopsia / Helicobacter pylori / Infecciones por Helicobacter Tipo de estudio: Diagnostic_studies Límite: Humans País/Región como asunto: America do sul / Brasil Idioma: En Revista: J. venom. anim. toxins incl. trop. dis Asunto de la revista: TOXICOLOGIA Año: 2012 Tipo del documento: Article País de afiliación: Brasil Pais de publicación: Brasil