Asociación inversa entre enfermedad de Alzheimer y cáncer / Inverse relationship between Alzheimer's disease and cancer
Rev. Hosp. Clin. Univ. Chile
; 20(3): 199-206, 2009. tab
Article
en Es
| LILACS
| ID: lil-620964
Biblioteca responsable:
CL36.1
ABSTRACT
The increase in life expectancy is accompanied by a concomitant increase in the prevalence of age related disorders, including neurodegenerative diseases, such as Alzheimers disease, Parkinsons disease, and various types of cancers. We here report epidemiologic findings suggesting thatthe development of the Alzheimer and a history of cancer are inversely related. The inverse relationship was found when all cancer types were analyzed and also when skin cancers (bothmelanomas and those with good prognosis, that constitute 50% of all cancers) were analyzed separately. In addition, in a population study we found that this inverse relationship was found with dementia of the Alzheimer type and mixed dementia, but not with vascular dementia, suggesting that the association is only with degenerative diseases. We discuss possible explanations for this inverse relationship, among them, the possibility that a common biological mechanism might be regulated in opposite directions in neurodegenerative diseases and cancer.
Texto completo:
1
Colección:
01-internacional
Base de datos:
LILACS
Asunto principal:
Enfermedad de Alzheimer
/
Neoplasias
Tipo de estudio:
Prognostic_studies
/
Risk_factors_studies
Límite:
Aged
/
Aged80
/
Female
/
Humans
/
Male
Idioma:
Es
Revista:
Rev. Hosp. Clin. Univ. Chile
Asunto de la revista:
MEDICINA
Año:
2009
Tipo del documento:
Article
País de afiliación:
Chile
Pais de publicación:
Chile