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Immunological studies and in vitro schistosomicide action of new imidazolidine derivatives
Neves, J. K. A. L; Sarinho, S; de Melo, C. M. L; Pereira, V. R. A; de Lima, M. C. A; Pitta, I. R; Albuquerque, M. C. P. A; Galdino, S. L.
Afiliación
  • Neves, J. K. A. L; Federal University of Pernambuco. Department of Antibiotics. Laboratory for Drug Design and Synthesis. Recife. BR
  • Sarinho, S; Federal University of Pernambuco. Department of Antibiotics. Laboratory for Drug Design and Synthesis. Recife. BR
  • de Melo, C. M. L; Oswaldo Cruz Foundation. Aggeu Magalhães Research Center. Department of Immunology. Recife. BR
  • Pereira, V. R. A; Oswaldo Cruz Foundation. Aggeu Magalhães Research Center. Department of Immunology. Recife. BR
  • de Lima, M. C. A; Federal University of Pernambuco. Department of Antibiotics. Laboratory for Drug Design and Synthesis. Recife. BR
  • Pitta, I. R; Federal University of Pernambuco. Department of Antibiotics. Laboratory for Drug Design and Synthesis. Recife. BR
  • Albuquerque, M. C. P. A; Federal University of Pernambuco. Immunopathology Laboratory Keizo Asami. Recife. BR
  • Galdino, S. L; Federal University of Pernambuco. Department of Antibiotics. Laboratory for Drug Design and Synthesis. Recife. BR
J. venom. anim. toxins incl. trop. dis ; 17(3): 277-286, 2011. graf, tab
Article en En | LILACS | ID: lil-597226
Biblioteca responsable: BR33.1
ABSTRACT
Schistosomiasis is a major public health problem with 207 million people infected and more than 779 million at risk. The drug of choice for treating schistosomiasis is praziquantel (PZQ); however, it is inefficient against immature forms of schistosomes. The aim of this study was to test new imidazolidine derivatives LPSF/PT09 and LPSF/PT10 against adult Schistosoma mansoni worms. IC50, cytotoxicity, immune response and cell viability assays were also available for these imidazolidines. Different concentrations of imidazolidine, from 32 to 320 »M, promoted motor abnormalities in breeding and unpaired worms, and death in 24 hours at higher concentrations. Although LPSF/PT09 and LPSF/PT10 did not affect IFN-³ and IL-10 production, they induced nitric oxide production and showed a similar behavior to praziquantel on cell death test. Thus, these new imidazolidine derivatives should undergo further study to develop schistosomiasis drugs.
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Texto completo: 1 Colección: 01-internacional Base de datos: LILACS Asunto principal: Schistosoma mansoni / Imidazolidinas Límite: Animals Idioma: En Revista: J. venom. anim. toxins incl. trop. dis Asunto de la revista: TOXICOLOGIA Año: 2011 Tipo del documento: Article País de afiliación: Brasil Pais de publicación: Brasil
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: LILACS Asunto principal: Schistosoma mansoni / Imidazolidinas Límite: Animals Idioma: En Revista: J. venom. anim. toxins incl. trop. dis Asunto de la revista: TOXICOLOGIA Año: 2011 Tipo del documento: Article País de afiliación: Brasil Pais de publicación: Brasil