Some optimal culture conditions for production of cyclosporin a by Fusarium roseum

Ismaiel, Ahmed A; El-Sayed, El-Sayed A; Mahmoud, Asmaa A

Ismaiel, Ahmed A; El-Sayed, El-Sayed A; Mahmoud, Asmaa A.

Afiliación

Ismaiel, Ahmed A; Zagazig University. Faculty of Science. Department of Botany. Zagazig. EG
El-Sayed, El-Sayed A; Zagazig University. Faculty of Science. Department of Botany. Zagazig. EG
Mahmoud, Asmaa A; Zagazig University. Faculty of Science. Department of Botany. Zagazig. EG

Braz. j. microbiol ; Braz. j. microbiol;41(4): 1112-1123, Oct.-Dec. 2010. ilus, graf, tab

Article en En | LILACS | ID: lil-595755

Biblioteca responsable: BR1.1

ABSTRACT

ABSTRACT

A suitable chemically defined culture medium was selected and some optimal conditions for the production of the highly immunosuppressive compound, cyclosporin A (Cyc A) are reported. Medium of the following composition was favorable for the production of Cyc A by Fusarium roseum glucose, 30; NaNO3, 2; KH2PO4, 1; MgSO4.7H2O, 0.5 and KCL, 0.5 (g/l). Maximum productivity of Cyc A was achieved at pH 6.0 when 50 ml of the fermentation medium/250 ml flask, inoculated with five fungal agar discs (6 mm, diameter) of 7-days old F. roseum culture after incubation at 30 ºC at 120 rpm for 7 days.

Palabras clave

Cyclosporin A; Fermentation conditions; Fusarium roseum

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Texto completo: 1 Colección: 01-internacional Base de datos: LILACS Idioma: En Revista: Braz. j. microbiol Asunto de la revista: MICROBIOLOGIA Año: 2010 Tipo del documento: Article País de afiliación: Egipto Pais de publicación: Brasil

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