Benznidazole levels in blood vary with age in rats
Mem. Inst. Oswaldo Cruz
; 106(3): 374-377, May 2011. tab
Article
en En
| LILACS
| ID: lil-589051
Biblioteca responsable:
BR1.1
ABSTRACT
Benznidazole (Bz) exhibits toxic side effects in animal studies and clinical use. Reductive metabolism of Bz in liver microsomes modulates the duration of its chemotherapeutic effect and its toxicity. The rate of this metabolism depends on age and is less intense in newborns and youngsters than in adults. In the present study, we determined Bz blood levels in rats of different ages that received Bz intragastrically (100 mg/kg). We developed and validated a high-pressure liquid chromatography with UV detector method for determination of Bz levels in whole blood. Bz levels were significantly higher and persisted for longer periods of time in the blood of young rats when compared to that of adult animals.
Palabras clave
Texto completo:
1
Colección:
01-internacional
Base de datos:
LILACS
Asunto principal:
Tripanocidas
/
Microsomas Hepáticos
/
Cromatografía Líquida de Alta Presión
/
Nitroimidazoles
Límite:
Animals
Idioma:
En
Revista:
Mem. Inst. Oswaldo Cruz
Asunto de la revista:
MEDICINA TROPICAL
/
PARASITOLOGIA
Año:
2011
Tipo del documento:
Article
País de afiliación:
Argentina
Pais de publicación:
Brasil