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A comparative study of p53 expression in hyperplastic, dysplastic epithelium and oral squamous cell carcinoma
Bansal, Sucheta; Sircar, Keya; Joshi, Sanjeev Kumar; Singh, Sanjeet; Rastogi, Varun.
Afiliación
  • Bansal, Sucheta; College of Dental Sciences and Research. Department of Oral and Maxillofacial Pathology. IN
  • Sircar, Keya; College of Dental Sciences and Research. Department of Oral and Maxillofacial Pathology. IN
  • Joshi, Sanjeev Kumar; College of Dental Sciences and Research. Department of Oral and Maxillofacial Pathology. IN
  • Singh, Sanjeet; College of Dental Sciences and Research. Department of Oral and Maxillofacial Pathology. IN
  • Rastogi, Varun; College of Dental Sciences and Research. Department of Oral and Maxillofacial Pathology. IN
Braz. j. oral sci ; 9(2): 85-88, Apr.-June 2010. ilus
Article en En | LILACS, BBO | ID: lil-578070
Biblioteca responsable: BR28.1
ABSTRACT

Aim:

To study oral hyperplastic epithelium, dysplastic epithelium and squamous cell carcinoma to determine (1) the prevalence of p53 protein immunoreactivity, (2) number of p53 positive cells, and (3) the area of localization of p53 protein immunoreactivity.

Methods:

Two contiguous sections from 30 tissue specimens (10 each from oral hyperplastic epithelium, dysplastic epithelium and squamous cell carcinoma) were subjected to hematoxylin and eosin (H/E) staining forhistopathological diagnosis and immunohistochemical (IHC) staining for demonstration of p53. p53 positivity was looked for in each IHC stained slide and the number of positive cells amongst 1,000 epithelial cells were recorded. The localization of these p53 positive cells within the strata (i.e.basal/suprabasal, spinous and superficial layers) of epithelium between 3 groups, and also with ineach group according to histological grades was recorded.

Results:

Higher p53 positive cell counts were demonstrated in oral squamous cell carcinoma compared to hyperplastic and dysplastic tissues. The expression of p53 in epithelial hyperkeratosis was mainly localized to basal epithelialcells whereas in epithelial dysplasia, it was predominantly localized to spinous epithelial cells.

Conclusions:

Qualitatively p53 is not a specific marker for malignancy of oral epithelium. However the quantitative analysis of p53 positive cells and their localization in oral epithelium is of importance as a marker for oral squamous cell carcinoma.
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Texto completo: 1 Colección: 01-internacional Base de datos: BBO / LILACS Asunto principal: Neoplasias de la Boca / Carcinoma de Células Escamosas / Hiperplasia Epitelial Focal Tipo de estudio: Risk_factors_studies Límite: Humans Idioma: En Revista: Braz. j. oral sci Asunto de la revista: ODONTOLOGIA Año: 2010 Tipo del documento: Article País de afiliación: India Pais de publicación: Brasil
Texto completo
Añadir a Mi BVS
Imprimir
XML
Buscar en Google
Texto completo: 1 Colección: 01-internacional Base de datos: BBO / LILACS Asunto principal: Neoplasias de la Boca / Carcinoma de Células Escamosas / Hiperplasia Epitelial Focal Tipo de estudio: Risk_factors_studies Límite: Humans Idioma: En Revista: Braz. j. oral sci Asunto de la revista: ODONTOLOGIA Año: 2010 Tipo del documento: Article País de afiliación: India Pais de publicación: Brasil