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Polymorphisms of cytochrome P450 1A1, glutathione s-transferases M1 and T1 genes in ouangolodougou (Northern Ivory Coast)
Santovito, Alfredo; Burgarello, Claudio; Cervella, Piero; Delpero, Massimiliano.
Afiliación
  • Santovito, Alfredo; University of Turin. Department of Animal and Human Biology. Torino. IT
  • Burgarello, Claudio; Biomedical Laboratory of the Catholic Mission. Oungolodougou.
  • Cervella, Piero; University of Turin. Department of Animal and Human Biology. Torino. IT
  • Delpero, Massimiliano; University of Turin. Department of Animal and Human Biology. Torino. IT
Genet. mol. biol ; 33(3): 434-437, 2010. tab
Article en En | LILACS | ID: lil-555829
Biblioteca responsable: BR26.1
ABSTRACT
In this study, the frequencies of CYP1A1, GSTM1, and GSTT1 gene polymorphisms were determined in 133 healthy individuals from Ouangolodougou, a small rural town situated in the north of the Ivory Coast. As appeared in several published studies, ethnic differences in these frequencies have been found to play an important role in the metabolism of a relevant number of human carcinogens. In the studied sample, the frequencies of Ile/Ile (wild type), Ile/Val (heterozygous variant), and Val/Val (homozygous variant) CYP1A1 genotypes were 0.271, 0.692, and 0.037, respectively. Frequencies of GSTM1 and GSTT1 null genotypes were 0.361 and 0.331, respectively. No significant differences were noted between men and women. In contrast to published data for Africans, CYP1A1 *Val Allele frequency (0.383) was significantly high (p < 0.001) in this specific population. For the GSTT1 null genotype, no differences were found between the studied and other African populations, the contrary to what occurred for the GSTM1 null genotype in relation to Gambia and Egypt.
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Texto completo: 1 Colección: 01-internacional Base de datos: LILACS Asunto principal: Polimorfismo Genético / Glutatión Transferasa Límite: Adult / Female / Humans / Male País/Región como asunto: Africa Idioma: En Revista: Genet. mol. biol Asunto de la revista: GENETICA Año: 2010 Tipo del documento: Article País de afiliación: Italia Pais de publicación: Brasil
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: LILACS Asunto principal: Polimorfismo Genético / Glutatión Transferasa Límite: Adult / Female / Humans / Male País/Región como asunto: Africa Idioma: En Revista: Genet. mol. biol Asunto de la revista: GENETICA Año: 2010 Tipo del documento: Article País de afiliación: Italia Pais de publicación: Brasil