Carcinoma subseroso de la vesícula biliar (pT2): valor pronóstico de la expresión de los genes supresores de tumores p53 y p27 en matrices de tejidos

Roa E, Iván; Lantadilla H, Soledad; Ibacache S, Gilda; de Aretxabala U, Xabier

Carcinoma subseroso de la vesícula biliar (pT2): valor pronóstico de la expresión de los genes supresores de tumores p53 y p27 en matrices de tejidos / p53 and p27 gene expression in subserosal gallbladder carcinoma

Roa E, Iván; Lantadilla H, Soledad; Ibacache S, Gilda; de Aretxabala U, Xabier.

Afiliación

Roa E, Iván; Clínica Alemana de Santiago. Servicio de Anatomía Patológica. CL
Lantadilla H, Soledad; Clínica Alemana de Santiago. Servicio de Anatomía Patológica. CL
Ibacache S, Gilda; Clínica Alemana de Santiago. Servicio de Anatomía Patológica. CL
de Aretxabala U, Xabier; Clínica Alemana de Santiago. Departamento de Cirugía. CL

Rev. méd. Chile ; 137(8): 1017-1022, ago. 2009. ilus, tab

Article en Es | LILACS | ID: lil-531991

Biblioteca responsable: BR1.1

ABSTRACT

ABSTRACT

Background:

Subserosal carcinoma is the stage that presents the greatest difficulty in the diagnosis therapeutic handling and prognosis evaluation. Aim To study the expression of p53 and p27 genes in subserosal gallbladder cancer. Material and

methods:

One hundred twenty seven tissue samples of subserosal gallbladder cancer (coming from 112 females aged 62 ± 13years and 15 men aged 67 ± 17years) and 50 control samples were selected to construct tissue arrays. p53 andp27genes were determined by immunohistochemistry.

Results:

Thirty eight percent of tumors were not detected at the macroscopic examination, 52 percent and 17 percent had lymph node and blood vessel involvement, respectively. Fifty six and 46 percent were positive for p53 and p27, respectively. No association between the expression of both genes and gender, degree of differentiation, lymph node or blood vessel involvement, was observed. Overall five years actuarial survival was 32 percent. Patients with positive or negative p53 expression had a 22 percent and 53 percent survival, respectively (p =0.05). No association between survival and p27 expression was observed.

Conclusions:

p53 gene expression is a prognostic factor for subserosal gallbladder cancer.

Asunto(s)

Anciano; Femenino; Humanos; Masculino; Persona de Mediana Edad; Carcinoma/genética; /genética; Neoplasias de la Vesícula Biliar/genética; Membrana Serosa; Biomarcadores de Tumor/genética; /genética; Carcinoma/mortalidad; Carcinoma/patología; Neoplasias de la Vesícula Biliar/mortalidad; Neoplasias de la Vesícula Biliar/patología; Pronóstico; Membrana Serosa/patología

Palabras clave

Gallbladder neoplasms; Genes; P27; P53

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Texto completo: 1 Colección: 01-internacional Base de datos: LILACS Asunto principal: Membrana Serosa / Carcinoma / Biomarcadores de Tumor / Neoplasias de la Vesícula Biliar Tipo de estudio: Prognostic_studies Límite: Aged / Female / Humans / Male Idioma: Es Revista: Rev. méd. Chile Asunto de la revista: MEDICINA Año: 2009 Tipo del documento: Article / Project document País de afiliación: Chile Pais de publicación: Chile

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