Alta prevalencia de trastorno específico de lenguaje en isla Robinson Crusoe y probable efecto fundador / High prevalence of specific language impairment in Robinson Crusoe Island. A possible founder effect
Rev. méd. Chile
; 136(2): 186-192, feb. 2008. ilus, tab
Article
en Es
| LILACS
| ID: lil-483238
Biblioteca responsable:
BR1.1
ABSTRACT
Specific language impairment (SLI) occurs in 2 percent to 8 percent of preschool children. Major and candidate genes are probably involved. Genetic drift is a cause for the presence of high frequencies of deleterious alíeles of a specific disease and the founder effect is one of its forms. Robinson Crusoe Island has 633 inhabitants and its actual population began with 8 families that repopulated the island at the end ofXIXth century. Aim To assess the frequency of specific language impairment among children living in Robinson Crusoe Island. Material and methods:
All 66 children aged between 3 and 9 years living in the island, were studied. Parents were interviewed and in children, non verbal intelligence, audiometric parameters, comprehension and expression of oral language were assessed. Extended genealogies were also performed.Results:
Forty children had at least one parent that was descending of founder families. Among these, 35 percent had SLI. Eighth five percent of SLI affected children came from the same colonizer family.Conclusions:
The prevalence of SLI in Robinson Crusoe Island is higher than that reponed in mainland Chile and abroad. This high prevalence, associated to a high frequency of consanguinity, supports the influence of genetic mechanisms in SLI transmission, based on a founder effect.Palabras clave
Texto completo:
1
Colección:
01-internacional
Base de datos:
LILACS
Asunto principal:
Efecto Fundador
/
Consanguinidad
/
Trastornos del Desarrollo del Lenguaje
Tipo de estudio:
Diagnostic_studies
/
Prevalence_studies
/
Risk_factors_studies
/
Screening_studies
Límite:
Child
/
Child, preschool
/
Female
/
Humans
/
Male
País/Región como asunto:
America do sul
/
Chile
Idioma:
Es
Revista:
Rev. méd. Chile
Asunto de la revista:
MEDICINA
Año:
2008
Tipo del documento:
Article
/
Project document
País de afiliación:
Chile
Pais de publicación:
Chile