General metabolism of the dimorphic and pathogenic fungus Paracoccidioides brasiliensis
Genet. mol. res. (Online)
; 4(2): 290-308, 30 jun. 2005. graf, tab
Article
en En
| LILACS
| ID: lil-445286
Biblioteca responsable:
BR1.1
ABSTRACT
Annotation of the transcriptome of the dimorphic fungus Paracoccidioides brasiliensis has set the grounds for a global understanding of its metabolism in both mycelium and yeast forms. This fungus is able to use the main carbohydrate sources, including starch, and it can store reduced carbons in the form of glycogen and trehalose; these provide energy reserves that are relevant for metabolic adaptation, protection against stress and infectivity mechanisms. The glyoxylate cycle, which is also involved in pathogenicity, is present in this fungus. Classical pathways of lipid biosynthesis and degradation, including those of ketone body and sterol production, are well represented in the database of P. brasiliensis. It is able to synthesize de novo all nucleotides and amino acids, with the sole exception of asparagine, which was confirmed by the fungus growth in minimal medium. Sulfur metabolism, as well as the accessory synthetic pathways of vitamins and co-factors, are likely to exist in this fungus.
Texto completo:
1
Colección:
01-internacional
Base de datos:
LILACS
Asunto principal:
Paracoccidioides
/
Transcripción Genética
/
Regulación Fúngica de la Expresión Génica
/
Etiquetas de Secuencia Expresada
Tipo de estudio:
Prognostic_studies
País/Región como asunto:
America do sul
/
Brasil
Idioma:
En
Revista:
Genet. mol. res. (Online)
Asunto de la revista:
BIOLOGIA MOLECULAR
/
GENETICA
Año:
2005
Tipo del documento:
Article
País de afiliación:
Brasil
Pais de publicación:
Brasil