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Modifications of the sympathetic skin response in workers chronically exposed to lead
Nora, D. B; Gomes, I; Said, G; Carvalho, F. M; Melo, A.
Afiliación
  • Nora, D. B; Universidade Federal do Rio Grande do Sul. Hospital de Clínicas de Porto Alegre. Serviço de Neurologia. Porto Alegre. BR
  • Gomes, I; Pontifícia Universidade Católica do Rio Grande do Sul. Hospital São Lucas. Serviço de Neurologia. Porto Alegre. BR
  • Said, G; Université Paris-Sud. Assistance Publique des Hôpitaux de Paris. Centre Hospitalier Universitaire de Bicêtre. Service de Neurologie. Paris. FR
  • Carvalho, F. M; Universidade Federal da Bahia. Faculdade de Medicina. Departamento de Medicina Preventiva. Salvador. BR
  • Melo, A; Universidade Federal da Bahia. Faculdade de Medicina. Divisão de Neurologia e Epidemiologia. Salvador. BR
Braz. j. med. biol. res ; 40(1): 81-87, Jan. 2007. tab
Article en En | LILACS | ID: lil-439672
Biblioteca responsable: BR1.1
ABSTRACT
The long-term effects of low-level lead intoxication are not known. The sympathetic skin response (SSR) was evaluated in a group of 60 former workers of a primary lead smelter, located in Santo Amaro, BA, Brazil. The individuals participating in the study were submitted to a clinical-epidemiological evaluation including questions related to potential risk factors for intoxication, complaints related to peripheral nervous system (PNS) involvement, neurological clinical examination, and also to electromyography and nerve conduction studies and SSR evaluation. The sample consisted of 57 men and 3 women aged 34 to 69 years (mean ± SD 46.8 ± 6.9). The neurophysiologic evaluation showed the presence of lumbosacral radiculopathy in one of the individuals (1.7 percent), axonal sensorimotor polyneuropathy in 2 (3.3 percent), and carpal tunnel syndrome in 6 (10 percent). SSR was abnormal or absent in 12 cases, representing 20 percent of the sample. More than half of the subjects (53.3 percent) reported a history of acute abdominal pain requiring hospitalization during the period of work at the plant. A history of acute palsy of radial and peroneal nerves was reported by about 16.7 and 8.3 percent of the individuals, respectively. Mean SSR amplitude did not differ significantly between patients presenting or not the various characteristics in the current neurological situation, except for diaphoresis. The results suggest that chronic lead intoxication induces PNS damage, particularly affecting unmyelinated small fibers. Further systematic study is needed to more precisely define the role of lead in inducing PNS injury.
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Texto completo: 1 Colección: 01-internacional Base de datos: LILACS Asunto principal: Sistema Nervioso Simpático / Exposición Profesional / Enfermedades del Sistema Nervioso Periférico / Respuesta Galvánica de la Piel / Plomo / Conducción Nerviosa Tipo de estudio: Diagnostic_studies / Etiology_studies / Risk_factors_studies Límite: Adult / Female / Humans / Male Idioma: En Revista: Braz. j. med. biol. res Asunto de la revista: BIOLOGIA / MEDICINA Año: 2007 Tipo del documento: Article País de afiliación: Brasil / Francia Pais de publicación: Brasil
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: LILACS Asunto principal: Sistema Nervioso Simpático / Exposición Profesional / Enfermedades del Sistema Nervioso Periférico / Respuesta Galvánica de la Piel / Plomo / Conducción Nerviosa Tipo de estudio: Diagnostic_studies / Etiology_studies / Risk_factors_studies Límite: Adult / Female / Humans / Male Idioma: En Revista: Braz. j. med. biol. res Asunto de la revista: BIOLOGIA / MEDICINA Año: 2007 Tipo del documento: Article País de afiliación: Brasil / Francia Pais de publicación: Brasil