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Defectos congénitos cráneo-encefálicos: variedades y respuesta a la fortificación de la harina con ácido fólico / Effect of flour folic acid fortification on the incidence of cranio encephalic congenital defects
Corral S., Edgardo; Moreno S., Rodrigo; Pérez G., Guillermo; Ojeda B., María Elena; Valenzuela G., Hernán; Reascos M., Mauricio; Sepúlveda L., Waldo.
Afiliación
  • Corral S., Edgardo; Hospital Regional. Servicio de Obstetricia y Ginecología. Unidad de Ecografía. Santiago. CL
  • Moreno S., Rodrigo; Universidad de Chile. Hospital Regional Rancagua. Unidad de Genética. Rancagua. CL
  • Pérez G., Guillermo; Hospital Regional Rancagua. Servicio de Anatomía Patológica. Rancagua. CL
  • Ojeda B., María Elena; Hospital Regional Rancagua. Servicio de Obstetricia y Ginecología. Unidad de Ecografía. Rancagua. CL
  • Valenzuela G., Hernán; Hospital Regional Rancagua. Servicio de Obstetricia y Ginecología. Unidad de Ecografía. Rancagua. CL
  • Reascos M., Mauricio; Universidad de Santiago de Chile. Programa de Formación como Especialista de Obstetricia y Ginecología. Santiago. CL
  • Sepúlveda L., Waldo; Clínica Las Condes. Departamento de Obstetricia y Ginecología. Unidad de Medicina Materno-Fetal. Santiago. CL
Rev. méd. Chile ; 134(9): 1129-1134, sept. 2006. ilus, tab
Article en Es, En | LILACS | ID: lil-438415
Biblioteca responsable: BR1.1
ABSTRACT

Background:

In Chile, flour is fortified with folic acid since 2000, and the incidence of neural tube defects has decreased. Cranio-encephalic congenital defects (CECD) have a wider clinical scope, includind classical neural tube defects (NTD) such as anencephalia and acrania, but also incorporating other defects. Therefore, the effects of folic acid fortification on the incidence of CECD could be different.

Aim:

To study the effect of folic acid fortification on the incidence of CECD. Material and

methods:

All prenatal diagnoses of CECD and cases registered locally in the Latin American Collaborative Study of Congenital Malformations (ECLAMC) were reviewed. The obtained data were crossed with all death certificates of newborns or stillborns of more than 500 g in the Sixth Region, in Central Chile. All cases were classified again in four subtypes, according to their phenotype. The incidences of all subtypes prior (1996-2000) and after folic acid supplementation (2001-2004), were compared.

Results:

Between 1996 and 2004, there were 64 cases of CEDC among 109,176 infants born alive. The global rate was 8.86 per 10,000 born alive in the period prior to fortification and 3.03 per 10,000 born alive after fortification. Comparing both periods, there was a 66 percent reduction in all CECD and a 77 and 100 percent reduction in subtypes A and B of CECD, respectively (p <0.05). No significant reductions in type C and D CECD, were observed.

Conclusions:

After the start of flour folic acid fortification, there was a global reduction in the incidence of CECD. However, only types A and B CECD, supposedly more responsive to folic acid, were reduced.
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Texto completo: 1 Colección: 01-internacional Base de datos: LILACS Asunto principal: Alimentos Fortificados / Harina / Ácido Fólico / Defectos del Tubo Neural Tipo de estudio: Incidence_studies / Prognostic_studies / Risk_factors_studies Límite: Humans / Newborn País/Región como asunto: America do sul / Chile Idioma: En / Es Revista: Rev. méd. Chile Asunto de la revista: MEDICINA Año: 2006 Tipo del documento: Article País de afiliación: Chile Pais de publicación: Chile
Texto completo
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Imprimir
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Texto completo: 1 Colección: 01-internacional Base de datos: LILACS Asunto principal: Alimentos Fortificados / Harina / Ácido Fólico / Defectos del Tubo Neural Tipo de estudio: Incidence_studies / Prognostic_studies / Risk_factors_studies Límite: Humans / Newborn País/Región como asunto: America do sul / Chile Idioma: En / Es Revista: Rev. méd. Chile Asunto de la revista: MEDICINA Año: 2006 Tipo del documento: Article País de afiliación: Chile Pais de publicación: Chile