Your browser doesn't support javascript.
loading
Cirrosis biliar primaria: experiencia de trece años en dos centros de referencia / Primary biliary cirrhosis: a thirteen years experience
Valera M., José Miguel; Smok S., Gladys; Poniachik T., Jaime; Oksenberg R., Danny; Silva P., Guillermo; Ferrario B., Mario; Buckel G., Erwin; Brahm B., Javier.
Afiliación
  • Valera M., José Miguel; Universidad de Chile. Hospital Clínico. Sección de Gastroenterología. Santiago. CL
  • Smok S., Gladys; Universidad de Chile. Hospital Clínico. Anatomía Patológica. Santiago. CL
  • Poniachik T., Jaime; Universidad de Chile. Hospital Clínico. Sección de Gastroenterología. Santiago. CL
  • Oksenberg R., Danny; Universidad de Chile. Hospital Clínico. Sección de Gastroenterología. Santiago. CL
  • Silva P., Guillermo; Clínica Las Condes. Departamento de Gastroenterología. Santiago. CL
  • Ferrario B., Mario; Clínica Las Condes. Unidad de Trasplante Hepático. Santiago. CL
  • Buckel G., Erwin; Clínica Las Condes. Unidad de Trasplante Hepático. Santiago. CL
  • Brahm B., Javier; Universidad de Chile. Hospital Clínico. Sección de Gastroenterología. Santiago. CL
Rev. méd. Chile ; 134(4): 469-474, abr. 2006. tab
Article en Es | LILACS | ID: lil-428547
Biblioteca responsable: BR1.1
RESUMO

Background:

Primary biliary cirrhosis (PBC) is a chronic cholestatic disease, which can progress to hepatic failure.

Aim:

To study the clinical presentation, pathological features, treatment and outcome of a group of patients with PBC. Material and

methods:

Retrospective review of medical records of 115 patients (110 females, age range 30-76 years) with PBC. Clinical presentation, pathological stage, treatment, outcome and eventual use of liver transplantation, were recorded.

Result:

Seventy eight percent of patients were symptomatic at presentation (itching in 69% and malaise in 62%). Antimitochondrial antibodies were positive in 56%. No clinical or laboratory differences were observed between symptomatic patients or those with positive antimitochondrial antibodies and the rest of the study group. Sjögren syndrome was present in 38%, hypothyroidism in 13%, scleroderma in 7% and rheumatoid arthritis in 5%. Initially, 61% had fibrosis and/or cirrhosis, and ursodeoxycholic acid was indicated in 94% of the patients. Fifteen patients underwent liver transplantation due to upper digestive bleeding or itching. Survival has been 67% at 36 months after transplantation. In one transplanted liver, PBC recurred.

Conclusions:

An early diagnosis and treatment of a progressive disease such as PBC will reduce the incidence of complications and the use of costly treatments.
Asunto(s)
Texto completo
Añadir a Mi BVS
Imprimir
XML
Buscar en Google
Texto completo: 1 Colección: 01-internacional Base de datos: LILACS Asunto principal: Cirrosis Hepática Biliar Tipo de estudio: Observational_studies / Prognostic_studies / Risk_factors_studies / Screening_studies Límite: Adult / Aged / Female / Humans / Male Idioma: Es Revista: Rev. méd. Chile Asunto de la revista: MEDICINA Año: 2006 Tipo del documento: Article País de afiliación: Chile Pais de publicación: Chile
Texto completo
Añadir a Mi BVS
Imprimir
XML
Buscar en Google
Texto completo: 1 Colección: 01-internacional Base de datos: LILACS Asunto principal: Cirrosis Hepática Biliar Tipo de estudio: Observational_studies / Prognostic_studies / Risk_factors_studies / Screening_studies Límite: Adult / Aged / Female / Humans / Male Idioma: Es Revista: Rev. méd. Chile Asunto de la revista: MEDICINA Año: 2006 Tipo del documento: Article País de afiliación: Chile Pais de publicación: Chile