Benznidazole-induced genotoxicity in diploid cells of Aspergillus nidulans

Kaneshima, Edilson N; Castro-Prado, Marialba A. Alves de

Kaneshima, Edilson N; Castro-Prado, Marialba A. Alves de.

Afiliación

Kaneshima, Edilson N; Universidade Estadual de Maringá. Departamento de Análises Clínicas. Maringá. BR
Castro-Prado, Marialba A. Alves de; Universidade Estadual de Maringá. Departamento de Biologia Celular e Genética. Maringá. BR

Mem. Inst. Oswaldo Cruz ; 100(3): 325-330, May 2005. ilus, tab

Article en En | LILACS | ID: lil-411033

Biblioteca responsable: BR1.1

ABSTRACT

ABSTRACT

Genotoxic effects of benznidazole were studied by the induction of homozygosis of genes previously present in heterozygous. UT448//A757 diploid strain was used in the benznidazole's recombinagenesis test. Although toxic effects on growth of colonies were not observed, 75 and 100 æM benznidazole induced an increasing of mitotic recombination events in diploid strain. Results were related to the induction of chromosomal breaks by the antiparasitic drug.

Asunto(s)

Aspergillus nidulans/efectos de los fármacos; Diploidia; Mutágenos/toxicidad; Nitroimidazoles/toxicidad; Aspergillus nidulans/citología; Aspergillus nidulans/genética; Homocigoto; Pruebas de Mutagenicidad; Mitosis/efectos de los fármacos; Mitosis/genética

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Texto completo: 1 Colección: 01-internacional Base de datos: LILACS Asunto principal: Aspergillus nidulans / Diploidia / Mutágenos / Nitroimidazoles Idioma: En Revista: Mem. Inst. Oswaldo Cruz Asunto de la revista: MEDICINA TROPICAL / PARASITOLOGIA Año: 2005 Tipo del documento: Article País de afiliación: Brasil Pais de publicación: Brasil

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