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Effect of propolis extract on guines pig lung mast cell
Orsi, R. O; Sforcin, J. M; Funari, S. R. C; Gomes, J. C.
Afiliación
  • Orsi, R. O; Universidade Estadual Paulista. School of Veterinary Medicine and Animal Husbrandy. Department of Animal Production. Botucatu. BR
  • Sforcin, J. M; Universidade Estadual Paulista. Institute of Biosciences. Department of Microbiology and Immunology. Botucatu. BR
  • Funari, S. R. C; Universidade Estadual Paulista. School of Veterinary Medicine and Animal Husbrandy. Department of Animal Production. Botucatu. BR
  • Gomes, J. C; Universidade Estadual Paulista. Institute of Biosciences. Department of Pharmacology. Botucatu. BR
J. venom. anim. toxins incl. trop. dis ; 11(1): 76-83, jan.-abr. 2005. graf
Article en En | LILACS, VETINDEX | ID: lil-396702
Biblioteca responsable: BR68.1
RESUMO
The direct effect of ethanolic extract of propolis on guinea pig lung cell suspension containing mast cells, as well as its influence on the histamine release induced by antigen (ovoalbumin 10 mug/ml) and ionophore A 23187 (3 muM) were investigated. Propolis ethanolic extract (300 mug/ml) increased the histamine release in guinea pig lung suspension containing mast cells by a cytotoxic effect. Lower concentrations of propolis had no effect on histamine release. Our results demonstrated that propolis (3, 10, 30, and 100 mug/ml) shows no significant effect on the histamine release induced by ionophore and antigen. Based on these results, we suggest that propolis could directly activate mast cells, promoting inflammatory mediators release by cytotoxic mechanisms, what could be related to allergic processes in propolis sensitive people.(AU)
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Texto completo: 1 Colección: 01-internacional Base de datos: LILACS / VETINDEX Asunto principal: Própolis / Histamina / Mastocitos Idioma: En Revista: J. venom. anim. toxins incl. trop. dis Asunto de la revista: TOXICOLOGIA Año: 2005 Tipo del documento: Article País de afiliación: Brasil Pais de publicación: Brasil
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: LILACS / VETINDEX Asunto principal: Própolis / Histamina / Mastocitos Idioma: En Revista: J. venom. anim. toxins incl. trop. dis Asunto de la revista: TOXICOLOGIA Año: 2005 Tipo del documento: Article País de afiliación: Brasil Pais de publicación: Brasil