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Functional evaluation of temporary focal cerebral ischemia: experimental model
Duarte, Sinésio Grace; Campos, Antônio Dorival; Colli, Benedicto Oscar.
Afiliación
  • Duarte, Sinésio Grace; University of Franca. Division of Neurosciences. Franca. BR
  • Campos, Antônio Dorival; University of Säo Paulo. Ribeiräo Preto Medical School. Department of Social Medicine. Ribeiräo Preto. BR
  • Colli, Benedicto Oscar; University of Säo Paulo. Ribeiräo Preto Medical School. Neurosurgical Division. Department of Surgery and Head. Ribeiräo Preto. BR
Arq. neuropsiquiatr ; Arq. neuropsiquiatr;61(3B): 751-756, Sept. 2003. tab, graf
Article en En | LILACS | ID: lil-348653
Biblioteca responsable: BR1.1
ABSTRACT

OBJECTIVE:

Despite cerebral ischemia being a frequent clinical pathologic state, the tolerance of neural tissue to oxygen absence and to reperfusion is controversial. This study aims to evaluate the effects of focal cerebral ischemia/reperfusion, by analyzing the mitochondrial respiration.

METHOD:

Sixty-four adult rats underwent focal cerebral ischemia by middle cerebral artery occlusion, during 15, 30 and 60 minutes, followed by 10 minutes or 19 hours of reperfusion. The effects of ischemia were analyzed measuring the O2 consumption by mitochondria in the ischemic and non-ischemic areas.

RESULTS:

There was compromise of the mitochondrial respiration after 30 and 60 minutes of ischemia, followed by 10 minutes of reperfusion but there was no alteration in this function after 19 hours of reperfusion.

CONCLUSION:

Compromise of the mitochondrial function occurred after 30 minutes of ischemia but, until one hour of ischemia, if the reperfusion was prolonged there was no evidence of ischemic/reperfusion injuries
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Texto completo: 1 Colección: 01-internacional Base de datos: LILACS Asunto principal: Consumo de Oxígeno / Daño por Reperfusión / Corteza Cerebral / Isquemia Encefálica / Mitocondrias Tipo de estudio: Prognostic_studies Límite: Animals Idioma: En Revista: Arq. neuropsiquiatr Asunto de la revista: NEUROLOGIA / PSIQUIATRIA Año: 2003 Tipo del documento: Article País de afiliación: Brasil Pais de publicación: Brasil
Texto completo
Añadir a Mi BVS
Imprimir
XML
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Texto completo: 1 Colección: 01-internacional Base de datos: LILACS Asunto principal: Consumo de Oxígeno / Daño por Reperfusión / Corteza Cerebral / Isquemia Encefálica / Mitocondrias Tipo de estudio: Prognostic_studies Límite: Animals Idioma: En Revista: Arq. neuropsiquiatr Asunto de la revista: NEUROLOGIA / PSIQUIATRIA Año: 2003 Tipo del documento: Article País de afiliación: Brasil Pais de publicación: Brasil