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Genetic relationships among native americans based on beta-globin gene cluster haplotype frequencies
Mousinho-Ribeiro, Rita de Cassia; Pante-de-Sousa, Gabriella; Santos, Eduardo José Melo dos; Guerreiro, João Farias.
Afiliación
  • Mousinho-Ribeiro, Rita de Cassia; Universidade Federal do Pará. Centro de Ciências Biológicas. Departamento de Fisiologia. Laboratório de Hematologia. Belém. BR
  • Pante-de-Sousa, Gabriella; Universidade Federal do Pará. Centro de Ciências Biológicas. Departamento de Fisiologia. Laboratório de Hematologia. Belém. BR
  • Santos, Eduardo José Melo dos; Universidade Federal do Pará. Centro de Ciências Biológicas. Departamento de Fisiologia. Laboratório de Hematologia. Belém. BR
  • Guerreiro, João Farias; Universidade Federal do Pará. Centro de Ciências Biológicas. Departamento de Patologia. Laboratório de Genética Humana e Médica. Belém. BR
Genet. mol. biol ; Genet. mol. biol;26(3): 229-234, 2003. ilus, tab
Article en En | LILACS | ID: lil-346308
Biblioteca responsable: BR26.1
ABSTRACT
The distribution of b-globin gene haplotypes was studied in 209 Amerindians from eight tribes of the Brazilian Amazon Asurini from Xingú, Awá-Guajá, Parakanä, Urubú-Kaapór, Zoé, Kayapó (Xikrin from the Bacajá village), Katuena, and Tiriyó. Nine different haplotypes were found, two of which (n. 11 and 13) had not been previously identified in Brazilian indigenous populations. Haplotype 2 (+ - - - -) was the most common in all groups studied, with frequencies varying from 70 percent to 100 percent, followed by haplotype 6 (- + + - +), with frequencies between 7 percent and 18 percent. The frequency distribution of the b-globin gene haplotypes in the eighteen Brazilian Amerindian populations studied to date is characterized by a reduced number of haplotypes (average of 3.5) and low levels of heterozygosity and intrapopulational differentiation, with a single clearly predominant haplotype in most tribes (haplotype 2). The Parakanä, Urubú-Kaapór, Tiriyó and Xavante tribes constitute exceptions, presenting at least four haplotypes with relatively high frequencies. The closest genetic relationships were observed between the Brazilian and the Colombian Amerindians (Wayuu, Kamsa and Inga), and, to a lesser extent, with the Huichol of Mexico. North-American Amerindians are more differentiated and clearly separated from all other tribes, except the Xavante, from Brazil, and the Mapuche, from Argentina. A restricted pool of ancestral haplotypes may explain the low diversity observed among most present-day Brazilian and Colombian Amerindian groups, while interethnic admixture could be the most important factor to explain the high number of haplotypes and high levels of diversity observed in some South-American and most North-American tribes
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Texto completo: 1 Colección: 01-internacional Base de datos: LILACS Asunto principal: Polimorfismo Genético / Variación Genética / Haplotipos / Globinas / Indígenas Sudamericanos Tipo de estudio: Prognostic_studies Límite: Humans País/Región como asunto: America do sul / Brasil Idioma: En Revista: Genet. mol. biol Asunto de la revista: GENETICA Año: 2003 Tipo del documento: Article País de afiliación: Brasil Pais de publicación: Brasil
Texto completo
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Imprimir
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Texto completo: 1 Colección: 01-internacional Base de datos: LILACS Asunto principal: Polimorfismo Genético / Variación Genética / Haplotipos / Globinas / Indígenas Sudamericanos Tipo de estudio: Prognostic_studies Límite: Humans País/Región como asunto: America do sul / Brasil Idioma: En Revista: Genet. mol. biol Asunto de la revista: GENETICA Año: 2003 Tipo del documento: Article País de afiliación: Brasil Pais de publicación: Brasil