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Evaluation of the immune response to CRA and FRA recombinant antigens of Trypanosoma cruzi in C57BL/6 mice
Pereira, Valéria Rêgo Alves; Lorena, Virginia Maria Barros de; Nakazawa, Mineo; Silva, Ana Paula Galvão da; Montarroyos, Ulisses; Correa-Oliveira, Rodrigo; Gomes, Yara de Miranda.
Afiliación
  • Pereira, Valéria Rêgo Alves; Fundação Oswaldo Cruz. Centro de Pesquisas Aggeu Magalhäes. Recife. BR
  • Lorena, Virginia Maria Barros de; Fundação Oswaldo Cruz. Centro de Pesquisas Aggeu Magalhäes. Recife. BR
  • Nakazawa, Mineo; Fundação Oswaldo Cruz. Centro de Pesquisas Aggeu Magalhäes. Recife. BR
  • Silva, Ana Paula Galvão da; Universidade Federal de Pernambuco. Recife. BR
  • Montarroyos, Ulisses; Fundação Oswaldo Cruz. Centro de Pesquisas Aggeu Magalhäes. Recife. BR
  • Correa-Oliveira, Rodrigo; Fundação Oswaldo Cruz. Centro de Pesquisas René Rachou. Belo Horizonte. BR
  • Gomes, Yara de Miranda; Fundação Oswaldo Cruz. Centro de Pesquisas Aggeu Magalhäes. Recife. BR
Rev. Soc. Bras. Med. Trop ; Rev. Soc. Bras. Med. Trop;36(4): 435-440, jul.-ago. 2003. graf
Article en En | LILACS | ID: lil-344765
Biblioteca responsable: BR1.1
ABSTRACT
Humoral and cellular immune responses were evaluated in 44 C57BL/6 mice immunized with the Trypanosoma cruzi recombinant antigens CRA and FRA. Both antigens induced cutaneous immediate-type hypersensitivity response. The levels of IgG1, IgG2a, IgG2b and IgG3 were high in CRA immunized mice. IgG3 was the predominant isotype. Although no difference in antibody levels was observed in FRA-immunized mice when compared to control mice, both antigens were able to induce lymphoproliferation in immunized mice. Significant differences were observed between incorporation of [ H]- thymidine by spleen cell stimulated in vitro with CRA or FRA and the control group. These results suggest that CRA and FRA could be involved in mechanisms of resistance to Trypanosoma cruzi infection
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Texto completo: 1 Colección: 01-internacional Base de datos: LILACS Asunto principal: Trypanosoma cruzi Límite: Animals Idioma: En Revista: Rev. Soc. Bras. Med. Trop Asunto de la revista: MEDICINA TROPICAL Año: 2003 Tipo del documento: Article / Project document País de afiliación: Brasil Pais de publicación: Brasil
Texto completo
Añadir a Mi BVS
Imprimir
XML
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Texto completo: 1 Colección: 01-internacional Base de datos: LILACS Asunto principal: Trypanosoma cruzi Límite: Animals Idioma: En Revista: Rev. Soc. Bras. Med. Trop Asunto de la revista: MEDICINA TROPICAL Año: 2003 Tipo del documento: Article / Project document País de afiliación: Brasil Pais de publicación: Brasil