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Use of tacrolimus in rescue therapy of acute and chronic rejection in liver transplantation
Coelho, Fabricio Ferreira; Coelho, Rafael Ferreira; Massarollo, Paulo Celso Bosco; Mies, Sérgio.
Afiliación
  • Coelho, Fabricio Ferreira; University of Säo Paulo. Faculty of Medicine. Department of Surgery. Säo Paulo. BR
  • Coelho, Rafael Ferreira; University of Säo Paulo. Faculty of Medicine. Department of Surgery. Säo Paulo. BR
  • Massarollo, Paulo Celso Bosco; University of Säo Paulo. Faculty of Medicine. Department of Surgery. Säo Paulo. BR
  • Mies, Sérgio; University of Säo Paulo. Faculty of Medicine. Department of Surgery. Säo Paulo. BR
Rev. Hosp. Clin. Fac. Med. Univ. Säo Paulo ; 58(3): 141-146, 2003. ilus, tab, graf
Article en En | LILACS | ID: lil-342133
Biblioteca responsable: BR1.1
RESUMO

PURPOSE:

To study the indications and results of tacrolimus as rescue therapy for acute cellular or chronic rejection in liver transplantation. PATIENTS AND

METHODS:

Eighteen liver transplant recipients who underwent rescue therapy with tacrolimus between March 1995 and August 1999 were retrospectively studied. The treatment indication, patients, and graft situation were recorded as of October 31st, 1999. The response to tacrolimus was defined as patient survival with a functional graft and histological reversal of acute cellular, or for chronic rejection, bilirubin serum levels decreasing to up to twice the upper normal limit.

RESULTS:

Fourteen cases (77.8 percent) presented a good response. The response rate for the different indications was (1) acute cellular + sepsis - 0/1 case; (2) recurrent acute cellular - 1/1 case; (3) OKT3-resistant acute cellular - 2/2 cases; (4) steroid-resistant acute cellular + active viral infection - 3/3 cases; (5) chronic rejection - 8/11 cases (72.7 percent response rate). The 4 patients who did not respond died.

CONCLUSION:

Tacrolimus rescue therapy was successful in most cases of acute cellular and chronic rejection in liver transplantation
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Texto completo: 1 Colección: 01-internacional Base de datos: LILACS Asunto principal: Trasplante de Hígado / Tacrolimus / Rechazo de Injerto / Inmunosupresores Tipo de estudio: Observational_studies / Prognostic_studies Límite: Adolescent / Adult / Humans Idioma: En Revista: Rev. Hosp. Clin. Fac. Med. Univ. Säo Paulo Asunto de la revista: MEDICINA Año: 2003 Tipo del documento: Article País de afiliación: Brasil Pais de publicación: Brasil
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: LILACS Asunto principal: Trasplante de Hígado / Tacrolimus / Rechazo de Injerto / Inmunosupresores Tipo de estudio: Observational_studies / Prognostic_studies Límite: Adolescent / Adult / Humans Idioma: En Revista: Rev. Hosp. Clin. Fac. Med. Univ. Säo Paulo Asunto de la revista: MEDICINA Año: 2003 Tipo del documento: Article País de afiliación: Brasil Pais de publicación: Brasil