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Prevalence of human papillomavirus DNA in female cervical lesions from Rio de Janeiro, Brazil
Cavalcanti, S. M. B; Frugulhetti, I. C. P; Passos, M. R. L; Fonseca, M. E. F; Oliveira, L. H. S.
Afiliación
  • Cavalcanti, S. M. B; Universidade Federal Fluminense (UFF). Instituto Biomédico. Departamento de Microbiologia e Parasitologia. Niterói. BR
  • Frugulhetti, I. C. P; Universidade Federal Fluminense (UFF). Instituto Biomédico. Departamento de Microbiologia e Parasitologia. Niterói. BR
  • Passos, M. R. L; Universidade Federal Fluminense (UFF). Instituto Biomédico. Departamento de Microbiologia e Parasitologia. Niterói. BR
  • Fonseca, M. E. F; Universidade Federal do Rio de Janeiro (UFRJ). Instituto de Microbiologia. Departamento de Virologia. BR
  • Oliveira, L. H. S; Universidade Federal Fluminense (UFF). Instituto Biomédico. Departamento de Microbiologia e Parasitologia. Niterói. BR
Mem. Inst. Oswaldo Cruz ; 89(4): 575-580, Oct.-Dec. 1994.
Article en En | LILACS | ID: lil-319935
Biblioteca responsable: BR1.1
ABSTRACT
A hundred-sixty paraffin-embedded specimens from female cervical lesions were examined for human papillomavirus (HPV) types 6, 11, 16 and 18 infections by non-isotopic in situ hybridization. The data were compared with histologic diagnosis. Eighty-eight (55) biopsies contained HPV DNA sequences. In low grade cervical intraepithelial neoplasias (CIN I), HPV infection was detected in 78.7 of the cases, the benign HPV 6 was the most prevalent type. HPV DNA was detected in 58 of CIN II and CIN III cases and in 41.8 of squamous cell carcinomas (SCC). Histologically normal women presented 20 of HPV infection. Oncogenic HPV was found in 10 of these cases, what may indicate a higher risk of developing CINs and cancer. Twenty-five percent of the infected tissues contained mixed infections. HPV 16 was the most common type infecting the cervix and its prevalence raised significantly with the severity of the lesions, pointing its role in cancer pathogenesis. White women presented twice the cervical lesions of mulatto and African origin women, although HPV infection rates were nearly the same for the three groups (approximately 50). Our results showed that HPV typing by in situ hybridization is a useful tool for distinguishing between low and high risk cervical lesions. Further studies are required to elucidate risk factors associated with HPV infection and progression to malignancy in Brazilian population.
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Texto completo: 1 Colección: 01-internacional Base de datos: LILACS Asunto principal: Papillomaviridae / Infecciones Tumorales por Virus / Displasia del Cuello del Útero / Neoplasias del Cuello Uterino / Infecciones por Papillomavirus Tipo de estudio: Etiology_studies / Prevalence_studies / Risk_factors_studies Límite: Female / Humans País/Región como asunto: America do sul / Brasil Idioma: En Revista: Mem. Inst. Oswaldo Cruz Asunto de la revista: MEDICINA TROPICAL / PARASITOLOGIA Año: 1994 Tipo del documento: Article País de afiliación: Brasil Pais de publicación: Brasil
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: LILACS Asunto principal: Papillomaviridae / Infecciones Tumorales por Virus / Displasia del Cuello del Útero / Neoplasias del Cuello Uterino / Infecciones por Papillomavirus Tipo de estudio: Etiology_studies / Prevalence_studies / Risk_factors_studies Límite: Female / Humans País/Región como asunto: America do sul / Brasil Idioma: En Revista: Mem. Inst. Oswaldo Cruz Asunto de la revista: MEDICINA TROPICAL / PARASITOLOGIA Año: 1994 Tipo del documento: Article País de afiliación: Brasil Pais de publicación: Brasil