In vitro antimicrobial activity of the aminoglycoside arbekacin tested against oxacillin-resistant Staphylococcus aureus isolated in brasilian hospitals
Braz. j. infect. dis
; 5(3): 130-135, Jun. 2001. ilus, tab
Article
en En
| LILACS
| ID: lil-301196
Biblioteca responsable:
BR11.1
RESUMO
Arbekacin is an aminoglycoside used in Japan for treating infections caused by gentamicin and oxacillin-resistant S.aureus (ORSA). The objective of this study was to determine the in vitro antimicrobial activity of arbekacin against 454 clinical isolates of ORSA. The isolates were consecutively collected between January and July, 2000, from patients hospitalized in8 Brazilian medical centers. The antimicrobial susceptibillity testing was performed by disk diffusion method according to NCCLS recommendations. The vast majority of the isolates, 453 strains (99.8 percent), were considered susceptible to arbekacin based on the criteria proposed by the Requirements for Antibiotic Products of Japan. Only 1 isolate (0.2 percent) was classified as resistant. On the other hand, high rates of resistance were demonstrated for other aminoglycosides, such as gentamicin (97.6 resistance) and amikacin (97.0 resistance). Resistance rate was also high for ciprofloxacin (98.0 percent). All isolates were considered susceptible to vancomycin. The excellent in vitro antimicrobial activity of arbekacin demonstrated in the study indicates that this antimicrobial agent may play an important role in the treatment of severe ORSA infections, especially those that show poor clinical response with vancomycin monotherapy. Since the aminoglycosides should not be used as monotherapy to treat Gram positive infections, further studies evaluating in vitro and in vivo synergistic activity of arbekacin combinations are necessary to clarify the clinical role of this aminoglycoside.
Texto completo:
1
Colección:
01-internacional
Base de datos:
LILACS
Asunto principal:
Oxacilina
/
Staphylococcus aureus
/
Técnicas In Vitro
/
Infección Hospitalaria
/
Antibacterianos
Tipo de estudio:
Guideline
Límite:
Humans
País/Región como asunto:
America do sul
/
Brasil
Idioma:
En
Revista:
Braz. j. infect. dis
Asunto de la revista:
DOENCAS TRANSMISSIVEIS
Año:
2001
Tipo del documento:
Article
País de afiliación:
Brasil
Pais de publicación:
Brasil