La hiperuricemia es un marcador del umbral anaeróbico en la insuficiencia cardíaca crónica / Hyperuricemia is a marker for anaerobic threshold in chronic cardiac failure
Rev. méd. Chile
; 129(5): 503-8, mayo 2001. tab, graf
Article
en Es
| LILACS
| ID: lil-295251
Biblioteca responsable:
CL1.1
ABSTRACT
Background:
Patients with chronic cardiac failure often have elevated plasma uric acid levels, that are associated to a dismal prognosis.Aim:
To investigate possible metabolic mechanisms to explain elevated uric acid levels in these patients. Patients andmethods:
Eighteen patients with chronic cardiac failure aged 61 ñ 10 years old, without gout or renal failure and not using high doses of diuretics (equal or less than 80 mg/day furosemide or 50 mg/day hydrochlorothiazide) were studied. Plasma uric acid levels were correlated with anaerobic threshold, maximal oxygen uptake, plasma noradrenaline and creatinine and left ventricular ejection fraction, measured radioisotopically.Results:
Mean maximal oxygen uptake was 16.6 ñ 4.2 ml/kg/min. There was a negative correlation between uric acid levels and maximal oxygen uptake or maximal oxygen uptake/body surface area (r=0.521 and -0.533 respectively, p<0.05). Patients with uric acid levels over 7 mg/dl had a lower anaerobic threshold than patients with lower levels (9.81 ñ 2.41 and 13.08 ñ 3.28 ml/kg/min respectively, p<0.05). No significant differences in maximal oxygen uptake were observed in these two groups of patients (15.5 ñ 4.24 and 18.08 ñ 3.86 ml/kg/min respectively). Uric acid levels did not correlate with plasma noradrenaline, creatinine or lefi ventricular ejection fraction.Conclusions:
These results suggest that a defect in cellular oxygenation contributes to the elevation of plasma uric acid levels in patients with chronic cardiac failure
Texto completo:
1
Colección:
01-internacional
Base de datos:
LILACS
Asunto principal:
Ácido Úrico
/
Umbral Anaerobio
/
Insuficiencia Cardíaca
Tipo de estudio:
Diagnostic_studies
/
Etiology_studies
/
Prognostic_studies
Límite:
Humans
/
Male
Idioma:
Es
Revista:
Rev. méd. Chile
Asunto de la revista:
MEDICINA
Año:
2001
Tipo del documento:
Article
/
Project document
Pais de publicación:
Chile