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Immunochemotherapy in American cutaneous leishmaniasis: immunological aspects before and after treatment
Toledo, V. P. C. P; Mayrink, W; Gollob, K. J; Oliveira, M. A. P; Costa, C. A Da; Genaro, O; Pinto, J. A; Afonso, L. C. C.
Afiliación
  • Toledo, V. P. C. P; Universidade Federal de Minas Gerais. Faculdade de Farmácia. Departamento de Análises Clínicas e Toxicológicas. Belo Horizonte. BR
  • Mayrink, W; Universidade Federal de Minas Gerais. Instituto de Ciências Biológicas. Departamento de Parasitologia. Belo Horizonte. BR
  • Gollob, K. J; Universidade Federal de Minas Gerais. Instituto de Ciências Biológicas. Departamento de Bioquímica e Imunologia. Belo Horizonte. BR
  • Oliveira, M. A. P; Universidade Federal de Minas Gerais. Instituto de Ciências Biológicas. Departamento de Bioquímica e Imunologia. Belo Horizonte. BR
  • Costa, C. A Da; Universidade Federal de Minas Gerais. Faculdade de Farmácia. Departamento de Análises Clínicas e Toxicológicas. Belo Horizonte. BR
  • Genaro, O; Universidade Federal de Minas Gerais. Instituto de Ciências Biológicas. Departamento de Bioquímica e Imunologia. Belo Horizonte. BR
  • Pinto, J. A; Universidade Federal de Minas Gerais. Faculdade de Medicina. Departamento de Pediatria. Belo Horizonte. BR
  • Afonso, L. C. C; Universidade Federal de Ouro Preto. Instituto de Ciências Exatas e Biológicas. Nupeb. Departamento de Ciências Biológicas. Ouro Preto. BR
Mem. Inst. Oswaldo Cruz ; 96(1): 89-98, Jan. 2001. ilus, tab
Article en En | LILACS | ID: lil-281634
Biblioteca responsable: BR1.1
ABSTRACT
In this study, we evaluated the immune response of patients suffering from cutaneous leishmaniasis treated with two distinct protocols. One group was treated with conventional chemotherapy using pentavalent antimonium salts and the other with immunochemotherapy where a vaccine against cutaneous leishmaniasis was combined with the antimonium salt. Our results show that, although no differences were observed in the necessary time for complete healing of the lesions between the two treatments, peripheral blood mononuclear cells from patients treated by chemotherapy showed smaller lymphoproliferative responses at the end of the treatment than those from patients in the immunochemotherapy group. Furthermore, IFN-gamma production was also different between the two groups. While cells from patients in the chemotherapy group produced more IFN-gamma at the end of treatment, a significant decrease in this cytokine production was associated with healing in the immunochemotherapy group. In addition, IL-10 production was also less intense in this latter group. Finally, an increase in CD8+ -IFN-gamma producing cells was detected in the chemotherapy group. Together these results point to an alternative treatment protocol where healing can be induced with a decreased production of a potentially toxic cytokine
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Texto completo: 1 Colección: 01-internacional Base de datos: LILACS Asunto principal: Vacunas Antiprotozoos / Interferón gamma / Leishmaniasis Cutánea / Leishmania / Antiprotozoarios Tipo de estudio: Clinical_trials / Guideline Límite: Adult / Female / Humans / Male Idioma: En Revista: Mem. Inst. Oswaldo Cruz Asunto de la revista: MEDICINA TROPICAL / PARASITOLOGIA Año: 2001 Tipo del documento: Article País de afiliación: Brasil Pais de publicación: Brasil
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: LILACS Asunto principal: Vacunas Antiprotozoos / Interferón gamma / Leishmaniasis Cutánea / Leishmania / Antiprotozoarios Tipo de estudio: Clinical_trials / Guideline Límite: Adult / Female / Humans / Male Idioma: En Revista: Mem. Inst. Oswaldo Cruz Asunto de la revista: MEDICINA TROPICAL / PARASITOLOGIA Año: 2001 Tipo del documento: Article País de afiliación: Brasil Pais de publicación: Brasil